Protein detail

CTND1

Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))

Entry name CTND1	UniProt ID O60716	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))

Protein Class (7)

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters

Protein Function (6)

Cancer-related genes:Mutational cancer driver genes
Predicted intracellular proteins
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of skin
Transporters:Accessory Factors Involved in Transport
Disease related genes

Ensembl

ENSG00000198561

Entrez Gene Symbol

CTNND1

Gene Synonym (5)

CTNNDKIAA0384p120p120casp120ctn

Gene Description

Catenin delta 1

Chromosome

Position

57753243-57819546

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificlymphoid tissueCell SpecificcDCSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificT-regBlood Lineage SpecificT-cells

Function & Pathway8

Protein Function (6)

Cancer-related genes:Mutational cancer driver genes
Predicted intracellular proteins
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of skin
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (19)

Page 1 of 2

Molecular Function (6)

Biological Process (3)

KEGG (4)

Reactome (16)

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Canonical Pathways (2)

M8626 Sig bcr signaling pathway
M10 Pid bcr 5pathway

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence81

Enzyme-Mediated Modification (48)

48 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CTNND1	EGFR	P00533	Y	321	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:15951569
CTNND1	EGFR	P00533	Y	334	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:15951569
CTNND1	PRKCE	Q02156	S	268	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:23542175 ProtMapper:21251911 ProtMapper:23542175 ProtMapper:27516388 SIGNOR:21251911
CTNND1	GSK3B	P49841	T	310	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	ProtMapper:12885254 HPRD:12885254 SIGNOR:12885254 KEA:17081983 KEA:12885254
CTNND1	GSK3B	P49841	S	252	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	ProtMapper:12885254 HPRD:12885254 SIGNOR:12885254 HPRD:18212344 KEA:12885254 HPRD:20166139
CTNND1	MAPK3	P27361	T	906	phosphorylation	PhosphoSite
CTNND1	MAPK3	P27361	T	310	phosphorylation	PhosphoSite
CTNND1	MAPK3	P27361	T	308	phosphorylation	PhosphoSite
CTNND1	MAPK1	P28482	T	906	phosphorylation	PhosphoSite
CTNND1	MAPK1	P28482	T	310	phosphorylation	PhosphoSite

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Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	No	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network (19)

19 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KC1E	P49674	CTND1	O60716	Yes	Yes	Yes	PhosphoSite_ProtMapperiPTMnetSIGNORProtMapperKEASIGNOR_ProtMapperSPIKENetworKIN_KEASPIKE_LC	ProtMapper:3133391 SIGNOR:3133391 SPIKE:20940130 SPIKE_LC:20940130 KEA:17570479
CTND1	O60716	CADH1	P12830	Yes	Yes	No	WangSIGNORHPRDHINTBioGRIDIntActInnateDBSPIKE_LCLit-BM-17SPIKE	InnateDB:8660921 Lit-BM-17:19711372 Lit-BM-17:9535896 HPRD:11226248 HPRD:7542250 HINT:8660921 IntAct:19604117 HPRD:10225956 Lit-BM-17:25468996 HINT:22850631 HINT:17261850 HPRD:7651399 Lit-BM-17:12427869 Lit-BM-17:22752307 Lit-BM-17:22850631 HINT:7651399 Lit-BM-17:12707304 Lit-BM-17:22715382 Lit-BM-17:7876318 HINT:20371349 BioGRID:29207493 Lit-BM-17:10409703 BioGRID:12427869 InnateDB:17261850 SIGNOR:14610055 Lit-BM-17:21670201 HINT:12707304 HINT:25466890 HPRD:10409703 Lit-BM-17:7542250 HPRD:10931041 HINT:33961781 Lit-BM-17:24424122 HINT:19114997 HINT:12640114 Lit-BM-17:7651399 Lit-BM-17:23180380 Lit-BM-17:12640114 HINT:10409703 SPIKE:20940130 IntAct:24424122 Lit-BM-17:20371349 SPIKE_LC:20940130 HPRD:10629228 HINT:34591612
SRC	P12931	CTND1	O60716	Yes	Yes	No	WangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDRLIMS-P_ProtMapperPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperHPRD-phos	ProtMapper:26477567 ProtMapper:20974127 ProtMapper:32063714 HPRD-phos:18669648 ProtMapper:14996911 HPRD:11382764 ProtMapper:17194753 ProtMapper:18707149 HPRD-phos:14996911 ProtMapper:17016520 KEA:11382764 HPRD-phos:20068231 ProtMapper:17389395 SIGNOR:11382764 HPRD-phos:11382764 ProtMapper:19138410 ProtMapper:23457577 ProtMapper:11382764 HPRD-phos:18707149 HPRD-phos:17389395 ProtMapper:20068231 ProtMapper:18669648 HPRD-phos:17016520
CTND1	O60716	CADH3	P22223	Yes	Yes	No	InnateDBHPRDSIGNORBioGRID	InnateDB:8660921 HPRD:8660921 BioGRID:8660921 SIGNOR:14610055
CSF1R	P07333	CTND1	O60716	Yes	Yes	No	REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper	ProtMapper:21049007 SIGNOR:21049007
CTND1	O60716	VAV2	P52735	Yes	Yes	No	SIGNOR	SIGNOR:22946057
GSK3B	P49841	CTND1	O60716	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	ProtMapper:12885254 HPRD:12885254 SIGNOR:12885254 ProtMapper:20166139 KEA:17081983 HPRD-phos:18212344 ProtMapper:18212344 HPRD-phos:12885254 HPRD-phos:20166139 KEA:12885254
KPCE	Q02156	CTND1	O60716	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:23542175 PhosphoSite:32589661 ProtMapper:21251911 PhosphoSite:15684660 ProtMapper:27516388 ProtMapper:23542175 PhosphoSite:27516388 PhosphoSite:27321178 SIGNOR:21251911
PTPRM	P28827	CTND1	O60716	Yes	Yes	Yes	SIGNORDEPODHPRDWangSPIKE_LC	DEPOD:10753936 HPRD:15588985 SIGNOR:21998202 HPRD:10753936
SMUF1	Q9HCE7	CTND1	O60716	Yes	No	Yes	SIGNOR	SIGNOR:32010791

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CTNND1-GLIS2 complex	CTNND1 GLIS2	O60716 Q9BZE0	0:0	CORUM	CORUM:6599	17344476
	CTNND1 LONP1	O60716 P36776	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	12	37786918 32284825 33035814 35611462 29436780 37786918 37702715 34817906 28986585 30646616 33709510 38321535

Sequence, Structure & Domains17

Sequences

Length

968

Mass

108,170

Sequence

MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI

Alternative Products

Event=Alternative splicing, Alternative initiation; Named isoforms=32; Comment=Isoforms result of a combination of four transcription start sites and three alternatively spliced exons(A, B and C).; Name=1ABC; IsoId=O60716-1; Sequence=Displayed; Name=1AB; Synonyms=p120-1AB; IsoId=O60716-2; Sequence=VSP_006743; Name=1AC; IsoId=O60716-3; Sequence=VSP_006745; Name=1BC; Synonyms=p120-1A; IsoId=O60716-4; Sequence=VSP_006744; Name=1A; IsoId=O60716-5; Sequence=VSP_006743, VSP_006745; Name=1B; IsoId=O60716-6; Sequence=VSP_006743, VSP_006744; Name=1C; IsoId=O60716-7; Sequence=VSP_006744, VSP_006745; Name=1; IsoId=O60716-8; Sequence=VSP_006743, VSP_006744, VSP_006745; Name=2ABC; IsoId=O60716-9; Sequence=VSP_006740; Name=2AB; IsoId=O60716-10; Sequence=VSP_006740, VSP_006743; Name=2AC; IsoId=O60716-11; Sequence=VSP_006740, VSP_006745; Name=2BC; IsoId=O60716-12; Sequence=VSP_006740, VSP_006744; Name=2A; IsoId=O60716-13; Sequence=VSP_006740, VSP_006743, VSP_006745; Name=2B; IsoId=O60716-14; Sequence=VSP_006740, VSP_006743, VSP_006744; Name=2C; IsoId=O60716-15; Sequence=VSP_006740, VSP_006744, VSP_006745; Name=2; IsoId=O60716-16; Sequence=VSP_006740, VSP_006743, VSP_006744, VSP_006745; Name=3ABC; IsoId=O60716-17; Sequence=VSP_006741; Name=3AB; IsoId=O60716-18; Sequence=VSP_006741, VSP_006743; Name=3AC; IsoId=O60716-19; Sequence=VSP_006741, VSP_006745; Name=3BC; IsoId=O60716-20; Sequence=VSP_006741, VSP_006744; Name=3A; IsoId=O60716-21; Sequence=VSP_006741, VSP_006743, VSP_006745; Name=3B; IsoId=O60716-22; Sequence=VSP_006741, VSP_006743, VSP_006744; Name=3C; IsoId=O60716-23; Sequence=VSP_006741, VSP_006744, VSP_006745; Name=3; IsoId=O60716-24; Sequence=VSP_006741, VSP_006743, VSP_006744, VSP_006745; Name=4ABC; IsoId=O60716-25; Sequence=VSP_006742; Name=4AB; IsoId=O60716-26; Sequence=VSP_006742, VSP_006743; Name=4AC; IsoId=O60716-27; Sequence=VSP_006742, VSP_006745; Name=4BC; IsoId=O60716-28; Sequence=VSP_006742, VSP_006744; Name=4A; IsoId=O60716-29; Sequence=VSP_006742, VSP_006743, VSP_006745; Name=4B; IsoId=O60716-30; Sequence=VSP_006742, VSP_006743, VSP_006744; Name=4C; IsoId=O60716-31; Sequence=VSP_006742, VSP_006744, VSP_006745; Name=4; IsoId=O60716-32; Sequence=VSP_006742, VSP_006743, VSP_006744, VSP_006745

Alternative Sequence

1..323; Missing (in isoform 4ABC, isoform 4AB, isoform 4AC, isoform 4BC, isoform 4A, isoform 4B, isoform 4C and isoform 4); 1..101; Missing (in isoform 3ABC, isoform 3AB, isoform 3AC, isoform 3BC, isoform 3A, isoform 3B, isoform 3C and isoform 3); 1..54; Missing (in isoform 2ABC, isoform 2AB, isoform 2AC, isoform 2BC, isoform 2A, isoform 2B, isoform 2C and isoform 2); 626..631; Missing (in isoform 1AB, isoform 1A, isoform 1B, isoform 1, isoform 2AB, isoform 2A, isoform 2B, isoform 2, isoform 3AB, isoform 3A, isoform 3B, isoform 3, isoform 4AB, isoform 4A, isoform 4B and isoform 4); 880..900; Missing (in isoform 1BC, isoform 1B, isoform 1C, isoform 1, isoform 2BC, isoform 2B, isoform 2C, isoform 2, isoform 3BC, isoform 3B, isoform 3C, isoform 3, isoform 4BC, isoform 4B, isoform 4C and isoform 4); 937..965; Missing (in isoform 1AC, isoform 1A, isoform 1C, isoform 1, isoform 2AC, isoform 2A, isoform 2C, isoform 2, isoform 3AC, isoform 3A, isoform 3C, isoform 3, isoform 4AC, isoform 4A, isoform 4C and isoform 4)

3D Structural Models

Turn

841..843

Helix

368..374; 380..394; 398..406; 409..415; 416..418; 422..435; 441..449; 452..462; 466..479; 483..485; 486..492; 494..500; 502..506; 524..537; 542..550; 554..567; 574..587; 590..593; 655..660; 662..674; 678..692; 697..706; 709..717; 718..720; 724..738; 744..757; 766..768; 772..786; 790..798; 801..809; 816..830; 833..840; 846..849

Beta Strand

437..439; 759..763; 812..814

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

875..888; Basic and acidic residues; 889..908; Polar residues; 909..922; Basic and acidic residues

Repeat

358..395; ARM 1; 398..437; ARM 2; 441..475; ARM 3; 476..516; ARM 4; 534..573; ARM 5; 583..624; ARM 6; 653..693; ARM 7; 700..739; ARM 8; 740..780; ARM 9; 781..826; ARM 10

Motif

O60716-2:622..629; Nuclear localization signal (NLS); O60716-5:622..629; Nuclear localization signal (NLS); O60716-6:622..629; Nuclear localization signal (NLS); O60716-8:622..629; Nuclear localization signal (NLS); O60716-10:568..575; Nuclear localization signal (NLS); O60716-13:622..629; Nuclear localization signal (NLS); O60716-14:622..629; Nuclear localization signal (NLS); O60716-16:622..629; Nuclear localization signal (NLS); O60716-18:521..528; Nuclear localization signal (NLS); O60716-21:521..528; Nuclear localization signal (NLS); O60716-22:521..528; Nuclear localization signal (NLS); O60716-24:521..528; Nuclear localization signal (NLS); O60716-26:299..306; Nuclear localization signal (NLS); O60716-29:299..306; Nuclear localization signal (NLS); O60716-30:299..306; Nuclear localization signal (NLS); O60716-32:299..306; Nuclear localization signal (NLS)

Coiled Coil

10..46

Domain (CC)

A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.; DOMAIN: ARM repeats 1 to 5 mediate interaction with cadherins.

Region

1..357; Necessary and sufficient for interaction with CCDC85B; 855..944; Disordered

Protein Families

Beta-catenin family

Sequence Similarities

Belongs to the beta-catenin family.

Clinical Relevance6

Disease Involvement (3)

Cancer-related genesDisease variantEctodermal dysplasia

Drugs (11)

PEXMETINIB TALMAPIMOD SB203580 PH-797804 TAK-715 COMPOUND 4E [PMID: 35546685]RALIMETINIB DORAMAPIMOD PAMAPIMOD VX-702 NEFLAMAPIMOD

Antibody (3)

CAB003837 HPA015954 HPA015955

Interaction Protein (7)

ENSG00000039068ENSG00000146648ENSG00000149177ENSG00000162407ENSG00000168036ENSG00000170558ENSG00000177485

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_opencell

Supporting Publications2

PMID	Title	Abstract
36394150	A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available