Protein detail

GAS7

Growth arrest-specific protein 7 (GAS-7)

Entry name GAS7	UniProt ID O60861	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Growth arrest-specific protein 7 (GAS-7)

Protein Class (3)

Cancer-related genesDisease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Cancer-related genes

Ensembl

ENSG00000007237

Entrez Gene Symbol

GAS7

Gene Synonym (2)

KIAA0394MGC1348

Gene Description

Growth arrest specific 7

Chromosome

Position

9910606-10198606

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway5

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Cancer-related genes

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence9

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
fbar_actin_dynamics_endocytosis	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GAS7 NCKIPSD	O60861 Q9NZQ3	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains12

Sequences

Length

476

Mass

54,371

Sequence

MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=3; IsoId=O60861-3; Sequence=Displayed; Name=1; IsoId=O60861-1; Sequence=VSP_035988; Name=2; Synonyms=GAS7-CB; IsoId=O60861-2; Sequence=VSP_006802, VSP_006803; Name=4; IsoId=O60861-4; Sequence=VSP_044294, VSP_044295

Alternative Sequence

1..140; Missing (in isoform 2); 1..64; Missing (in isoform 1); 1..60; Missing (in isoform 4); 61; E -> M (in isoform 4); 141..156; PPETAHMSVRKSTGDS -> MSNMENSFDDVSCLSP (in isoform 2)

3D Structural Models

Helix

54..56

Beta Strand

5..9; 28..32; 40..43; 49..52; 57..59; 84..87; 93..96; 98..100; 103..107

3D Structure

NMR spectroscopy (2)

Domain & Motif Annotations

Compositional Bias

108..120; Low complexity; 150..171; Polar residues

Coiled Coil

309..419

Domain (FT)

1..62; SH3; 77..110; WW; 196..456; F-BAR

Region

100..171; Disordered

Clinical Relevance2

Disease Involvement (2)

Cancer-related genesProto-oncogene

Antibody (2)

HPA004838 HPA064678

Supporting Publications1

PMID	Title	Abstract
27605433	Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.	No abstract available