Protein detail
G37L1
G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2)
Entry name G37L1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2)
Protein Class (2)
G-protein coupled receptorsPredicted membrane proteins
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
135..155; Helical; Name=1; 168..188; Helical; Name=2; 206..226; Helical; Name=3; 252..272; Helical; Name=4; 311..331; Helical; Name=5; 362..382; Helical; Name=6; 399..419; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
ETBR-LP-2
Gene Description
G protein-coupled receptor 37 like 1
Chromosome
1
Position
202122886-202133592
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificEpididymal efferent duct absorptive cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function (5)
Biological Process (3)
- GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- GO:0035603 fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- GO:0035604 fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
Reactome (5)
Canonical Pathways
M276 Pid fgf pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence55
Ligand-Receptor Signaling (54)
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| class_a_rhodopsin_orphan | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_orphan_class_a_orphans | receptor | GPCRdb | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | HPMR | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes |
Sequence, Structure & Domains
Sequences
Length
481
Mass
52,771
Sequence
MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC
Domain & Motif Annotations
Domain (CC)
The N-terminal region is required for constitutive signal transduction.
Region
26..58; Disordered; 70..108; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No related sentences available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No related sentences available |