Protein detail
NSMA
Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (nSMase1)
Entry name NSMA | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 2 | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (nSMase1)
Protein Class (4)
EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Transmembrane
330..350; Helical; 354..374; Helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
ISC1nSMase
Gene Description
Sphingomyelin phosphodiesterase 2
Chromosome
6
Position
109440724-109443919
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway7
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
KEGG (3)
Reactome (8)
- R-hsa-73887 death receptor signaling
- R-hsa-9840310 glycosphingolipid catabolism
- R-hsa-1660662 glycosphingolipid metabolism
- R-hsa-556833 metabolism of lipids
- R-hsa-193704 p75 ntr receptor mediated signalling
- R-hsa-428157 sphingolipid metabolism
- R-hsa-5626978 tnfr1 mediated ceramide production
- R-hsa-75893 tnf signaling
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence20
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| EXO1GPR89AHSPA13MLH1MSH2MSH3MSH6PCNAPMS2SMPD2SOX10UBC | B7ZAQ6O60906P0CG48P12004P20585P40692P43246P48723P52701P54278P56693Q9UQ84 | 1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9479 | ||
| ADH5JPH1SMPD2TP63TP73YWHAZ | O15350O60906P11766P63104Q9H3D4Q9HDC5 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6679 | ||
| SMPD2 | O60906 | 2 | PDB | PDB:8j2f |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains10
Sequences
Length
423
Mass
47,646
Sequence
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ
3D Structural Models
Turn
20..22; 63..66; 76..78; 107..109; 167..169; 225..228
Helix
26..40; 53..62; 111..114; 149..166; 186..195; 200..203; 211..213; 303..347; 354..400
Beta Strand
6..18; 43..50; 69..73; 82..88; 92..97; 117..125; 128..136; 143..145; 171..178; 205..210; 218..223; 238..244; 248..257; 265..267; 269..272; 275..283
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Region
400..423; Disordered
Protein Families
Neutral sphingomyelinase family
Sequence Similarities
Belongs to the neutral sphingomyelinase family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37329381 | Omega-3 Polyunsaturated Fatty Acids Protect Neurological Function After Traumatic Brain Injury by Suppressing Microglial Transformation to the Proinflammatory Phenotype and Activating Exosomal NGF/TrkA Signaling. | Omega-3 PUFA also prevented the reactive transformation of microglia and promoted the secretion of microglial exosomes containing nerve growth factor (NGF), activating the neuroprotective NGF/TrkA pathway both in culture and TBI model mice. |