Protein detail
KCJ13
Inward rectifier potassium channel 13 (Inward rectifier K(+) channel Kir7.1) (Potassium channel, inwardly rectifying subfamily J member 13)
Entry name KCJ13 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 2 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Inward rectifier potassium channel 13 (Inward rectifier K(+) channel Kir7.1) (Potassium channel, inwardly rectifying subfamily J member 13)
Protein Function (5)
- Voltage-gated ion channels:Inwardly Rectifying Potassium Channels
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
51..77; Helical; Name=M1; 132..157; Helical; Name=M2
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificEarly spermatidsSingle-Nuclei Brain Specificleukocyte
Function & Pathway6
Protein Function (5)
- Voltage-gated ion channels:Inwardly Rectifying Potassium Channels
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (2)
Molecular Function
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence23
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| KCNJ13 | PRKCA | P17252 | S | 201 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:18976636SIGNOR:18976636 |
| KCNJ13 | PRKACA | P17612 | S | 287 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:18976636SIGNOR:18976636 |
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | KCJ13 | O60928 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:18976636ProtMapper:18976636SIGNOR:18976636 |
| KAPCA | P17612 | KCJ13 | O60928 | Yes | Yes | No | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:18976636SIGNOR:18976636 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry|Western blottingMass spectrometryMass spectrometry [LTQ-FT Ultra] | 1 | 38278418 |
Sequence, Structure & Domains8
Sequences
Length
360
Mass
40,530
Sequence
MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAHMDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFPLTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFASLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60928-1; Sequence=Displayed; Name=2; Synonyms=Kir7.1S; IsoId=O60928-2; Sequence=VSP_042627, VSP_042628
Alternative Sequence
76..94; YVLAEMNGDLELDHDAPPE -> CFCGEDCPAKKSSFFNSLY (in isoform 2); 95..360; Missing (in isoform 2)
Domain & Motif Annotations
Motif
119..124; Selectivity filter
Protein Families (2)
- Inward rectifier-type potassium channel (TC 1.A.2.1) family
- KCNJ13 subfamily
Sequence Similarities
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ13 subfamily.
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 27601599 | Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components. | No abstract available |
| 31070281 | The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways. | No abstract available |
| 34571828 | Proteomic Analysis of Circulating Extracellular Vesicles Identifies Potential Biomarkers for Lymph Node Metastasis in Oral Tongue Squamous Cell Carcinoma. | No abstract available |
| 34771645 | GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer. | No abstract available |