Protein detail

SCN2B

Sodium channel regulatory subunit beta-2

Entry name
SCN2B
UniProt ID
O60939
EVMP confidence score
0.40
Supporting publications (n)
1
Transmembrane count
1
Protein classification
Basic Information
Protein Names
Sodium channel regulatory subunit beta-2
Protein Function (4)
  • Disease related genes
  • Human disease related genes:Cardiovascular diseases:Cardiac diseases
  • FDA approved drug targets:Small molecule drugs
  • Transporters:Accessory Factors Involved in Transport
Transmembrane
158..179; Helical
Transmembrane Count
1
Ensembl
ENSG00000149575
Entrez Gene Symbol
SCN2B
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificBreast lactating cellsBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function (4)
  • Disease related genes
  • Human disease related genes:Cardiovascular diseases:Cardiac diseases
  • FDA approved drug targets:Small molecule drugs
  • Transporters:Accessory Factors Involved in Transport
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
KEGG
hsa04519 Cadherin signaling
Reactome (8)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence43

Ligand-Receptor Signaling (37)

37 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
cell_surfacecell_surfaceSurfaceomeYes
cell_surfacecell_surfaceOmniPathYes
receptorreceptorCellinkerYesYes
transmembranetransmembrane_predictedPhobiusYes
transmembrane_phobiustransmembrane_predictedAlmen2009Yes
transmembrane_sosuitransmembrane_predictedAlmen2009Yes
transmembrane_tmhmmtransmembrane_predictedAlmen2009Yes
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Protein Complex Composition (5)

5 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
Nav1.3 voltage-gated sodium channel complexSCN1B-SCN2B variantSCN1BSCN2BSCN3AO60939Q07699Q9NY461:1:1ComplexPortalPDBPDB:7W7FPDB:7W77PDB:7w77PDB:7w7fintact:EBI-484304851868823522992729337125472247378314755292
Nav1.4 voltage-gated sodium channel complexSCN1B-SCN2B variantSCN1BSCN2BSCN4AO60939P35499Q076991:1:1ComplexPortalintact:EBI-48430676PDB:6AGF1868823522992729224737831475529230190309
Nav1.8 voltage-gated sodium channel complexSCN1B-SCN2B variantSCN10ASCN1BSCN2BO60939Q07699Q9Y5Y91:1:1ComplexPortalintact:EBI-48431636224737831475529222992729
Nav1.9 voltage-gated sodium channel complexSCN1B-SCN2B variantSCN11ASCN1BSCN2BO60939Q07699Q9UI331:1:1ComplexPortalintact:EBI-48431796224737831475529222992729
SCN2BO609392PDBPDB:5fdy

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryWestern blottingELISA737702715387318683007131833729255400983463869842030760538
Sequence, Structure & Domains

Sequences

Length
215
Mass
24,326
Sequence
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK

3D Structural Models

Turn
60..62; 96..98
Helix
93..95; 105..107; 119..121
Beta Strand
31..33; 36..41; 46..48; 51..53; 64..72; 73..75; 77..89; 99..101; 112..114; 123..130; 134..137; 138..147
3D Structure
Electron microscopy (30); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias
189..215; Basic and acidic residues
Domain (FT)
32..154; Ig-like C2-type
Region
187..215; Disordered
Protein Families
Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
Sequence Similarities
Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.
Clinical Relevance
Drugs
ZONISAMIDE
Supporting Publications1
PMIDTitleRelated sentences
38014595Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.No related sentences available