Protein detail

FCG3B

Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (CD16-I) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)

Protein symbol
FCG3B
UniProt ID
O75015
EVMP score
0.25
Frequency
1
Transmembrane count
Protein classification
Basic Information
Protein Names
Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (CD16-I) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)
Protein Function
  • Predicted intracellular proteins
  • CD markers
  • Predicted secreted proteins
  • Transporters:Accessory Factors Involved in Transport
  • Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
  • FDA approved drug targets:Biotech drugs
Ensembl
ENSG00000162747
Entrez Gene Symbol
FCGR3B
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specifichippocampal dentate gyrusSecretome LocationSecreted to bloodSecretome FunctionDevelopmental protein
Function & Pathway
Protein Function
  • Predicted intracellular proteins
  • CD markers
  • Predicted secreted proteins
  • Transporters:Accessory Factors Involved in Transport
  • Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
  • FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
  • M278 Pid rac1 pathway
  • M81 Pid cdc42 pathway
  • M164 Pid erbb1 downstream pathway
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

39 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorGO_IntercellNoYesYesYesYes
receptorreceptorHPMRNoYesYesYesYes
receptorreceptorICELLNETNoYesYesYesYes
receptorreceptorSurfaceomeNoYesYesYesYes
other_receptor_familyreceptorHPMRNoYesYesYesYes
transferrinreceptorHPMRNoYesYesYesYes
fcrreceptorSurfaceomeNoYesYesYesYes
igreceptorSurfaceomeNoYesYesYesYes
innate_immunereceptorICELLNETNoYesYesYesYes
receptorreceptorOmniPathNoYesYesYesYes
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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
FCGR3BIGHG1O75015P018571:2PDBPDB:1t89PDB:1t83PDB:1e4k
FCGR3BP0DOX5O75015P0DOX51:2PDBPDB:6eaq
FCGR3BKLHL20O75015Q9Y2M50:0hu.MAPhu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry138207106
Sequence, Structure & Domains

Sequences

Length
233
Mass
26,243
Sequence
MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQWFHNENLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFSPPGYQVSFCLVMVLLFAVDTGLYFSVKTNI

3D Structural Models

Helix
81..83; 131..133; 164..166
Beta Strand
27..32; 35..38; 43..48; 59..62; 65..70; 72..78; 85..90; 92..94; 100..105; 107..112; 116..119; 120..122; 124..130; 137..143; 146..153; 157..161; 168..176; 179..182; 186..191
3D Structure
X-ray crystallography (6)

Domain & Motif Annotations

Domain (FT)
40..96; Ig-like C2-type 1; 121..179; Ig-like C2-type 2
Clinical Relevance
Drugs
PUROMYCINMETHOTREXATEIL-18PENICILLINFAS LIGANDTETRADECANOYLPHORBOL ACETATECHOLECALCIFEROLEPOETIN ALFAPROTEASE INHIBITORSODIUM CHLORIDECYCLOSPORINEPROGESTINPICIBANILDOXORUBICIN HYDROCHLORIDECYTARABINEALDESLEUKINRECOMBINANT INTERLEUKIN-8BETA-GLUCANCHONDROITIN SULFATESLACTULOSEMAFOSFAMIDEPOLY ICTHALIDOMIDEIMMUNOTHERAPEUTIC AGENTPREDNISOLONEINDOMETHACINDIMETHYL SULFOXIDEGELDANAMYCINMETHIMAZOLELIFANGIOGENESIS INHIBITORHEPARINFENTANYL CITRATE