Protein detail

PLXA2

Plexin-A2 (Semaphorin receptor OCT)

Protein symbol PLXA2	UniProt ID O75051	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Plexin-A2 (Semaphorin receptor OCT)

Protein Class

Predicted membrane proteins

Transmembrane

1238..1258; Helical

Transmembrane Count

Ensembl

ENSG00000076356

Entrez Gene Symbol

PLXNA2

Gene Synonym

FLJ11751FLJ30634KIAA0463OCTPLXN2

Gene Description

Plexin A2

Chromosome

Position

208022242-208244384

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBergmann glia

Function & Pathway

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PLXNA2	FYN	P06241	Y	1,677	phosphorylation	PhosphoSite
PLXNA2	FYN	P06241	Y	1,605	phosphorylation	PhosphoSite
PLXNA2	PRKCA	P17252	S	1,623	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

52 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
plexin	receptor	Matrisome	No	Yes	No	Yes	No
plexins	receptor	HPMR	No	Yes	No	Yes	No

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Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SEM3B	Q13214	PLXA2	O75051	Yes	Yes	No	SIGNOR	SIGNOR:25335892
SEM3C	Q99985	PLXA2	O75051	Yes	Yes	No	SIGNOR	SIGNOR:19666519
SEM3A	Q14563	PLXA2	O75051	Yes	Yes	No	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACEHPMR_talklr	CellTalkDB:10934324 SIGNOR:10679438 LRdb:10934324
FYN	P06241	PLXA2	O75051	Yes	No	No	Sparser_ProtMapperPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:29091353 ProtMapper:29091353

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PLXNA2-RANBPM complex	PLXNA2 RANBP9	O75051 Q96S59	1:1	CompleatCORUM	CORUM:5758Compleat:HC1112	16672672
	LACRT LCN1 PLXNA2	O75051 P31025 Q9GZZ8	0:0:0	hu.MAP2

Isolation & Detection Technology

0 records.

Sequence, Structure & Domains

Sequences

Length

1,894

Mass

211,104

Sequence

MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75051-1; Sequence=Displayed; Name=2; IsoId=O75051-2; Sequence=VSP_017967, VSP_017968, VSP_017969

Alternative Sequence

1; M -> MGTLGQASLFAPPGNYFWSDHSALCFAESCEGQPGKVEQMSTHRSRLLTAAPLSM (in isoform 2); 458..498; IRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVM -> VRVYEFRCSNAIHLLSKESLLEGSYWWRFNYRQLYFLGEQR (in isoform 2); 499..1894; Missing (in isoform 2)

3D Structural Models

Turn

1558..1560

Helix

1525..1536; 1548..1550; 1584..1587

Beta Strand

1499..1504; 1515..1520; 1551..1557; 1561..1565; 1567..1569; 1594..1599

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Coiled Coil

1261..1310

Domain (FT)

35..508; Sema; 858..951; IPT/TIG 1; 954..1037; IPT/TIG 2; 1041..1139; IPT/TIG 3; 1143..1228; IPT/TIG 4

Protein Families

Plexin family

Sequence Similarities

Belongs to the plexin family.

Clinical Relevance

Antibody

CAB009763