Protein detail

PLXA2

Plexin-A2 (Semaphorin receptor OCT)

Entry name PLXA2	UniProt ID O75051	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Plexin-A2 (Semaphorin receptor OCT)

Protein Class

Predicted membrane proteins

Transmembrane

1238..1258; Helical

Transmembrane Count

Ensembl

ENSG00000076356

Entrez Gene Symbol

PLXNA2

Gene Synonym (5)

FLJ11751FLJ30634KIAA0463OCTPLXN2

Gene Description

Plexin A2

Chromosome

Position

208022242-208244384

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBergmann glia

Function & Pathway

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (6)

Mediation Categories (2)

Adhesion and uptake mediationReceptor-signaling mediation

Relations & Evidence61

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PLXNA2	FYN	P06241	Y	1,677	phosphorylation	PhosphoSite
PLXNA2	FYN	P06241	Y	1,605	phosphorylation	PhosphoSite
PLXNA2	PRKCA	P17252	S	1,623	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (52)

52 records.

Category	Parent	Database	Plasma Membrane (Transmembrane)
transmembrane	transmembrane	LOCATE	Yes
transmembrane	transmembrane	Ramilowski_location	Yes
transmembrane	transmembrane	OmniPath	Yes
plasma_membrane	plasma_membrane	UniProt_location	Yes
plasma_membrane	plasma_membrane	Cellinker	Yes
plasma_membrane	plasma_membrane	OmniPath	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	Yes

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Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Database	References
SEM3B	Q13214	PLXA2	O75051	Yes	Yes	SIGNOR	SIGNOR:25335892
SEM3C	Q99985	PLXA2	O75051	Yes	Yes	SIGNOR	SIGNOR:19666519
SEM3A	Q14563	PLXA2	O75051	Yes	Yes	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACEHPMR_talklr	CellTalkDB:10934324 SIGNOR:10679438 LRdb:10934324
FYN	P06241	PLXA2	O75051	Yes		Sparser_ProtMapperPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:29091353 ProtMapper:29091353

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PLXNA2-RANBPM complex	PLXNA2 RANBP9	O75051 Q96S59	1:1	CompleatCORUM	CORUM:5758Compleat:HC1112	16672672
	LACRT LCN1 PLXNA2	O75051 P31025 Q9GZZ8	0:0:0	hu.MAP2

Sequence, Structure & Domains

Sequences

Length

1,894

Mass

211,104

Sequence

MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75051-1; Sequence=Displayed; Name=2; IsoId=O75051-2; Sequence=VSP_017967, VSP_017968, VSP_017969

Alternative Sequence

1; M -> MGTLGQASLFAPPGNYFWSDHSALCFAESCEGQPGKVEQMSTHRSRLLTAAPLSM (in isoform 2); 458..498; IRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVM -> VRVYEFRCSNAIHLLSKESLLEGSYWWRFNYRQLYFLGEQR (in isoform 2); 499..1894; Missing (in isoform 2)

3D Structural Models

Turn

1558..1560

Helix

1525..1536; 1548..1550; 1584..1587

Beta Strand

1499..1504; 1515..1520; 1551..1557; 1561..1565; 1567..1569; 1594..1599

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Coiled Coil

1261..1310

Domain (FT)

35..508; Sema; 858..951; IPT/TIG 1; 954..1037; IPT/TIG 2; 1041..1139; IPT/TIG 3; 1143..1228; IPT/TIG 4

Protein Families

Plexin family

Sequence Similarities

Belongs to the plexin family.

Clinical Relevance

Antibody

CAB009763

Supporting Publications1

PMID	Title	Related sentences
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No related sentences available