Protein detail

PLXA2

Plexin-A2 (Semaphorin receptor OCT)

Protein symbol PLXA2	UniProt ID O75051	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Plexin-A2 (Semaphorin receptor OCT)

Protein Class

Predicted membrane proteins

Transmembrane

1238..1258; Helical

Transmembrane Count

Ensembl

ENSG00000076356

Entrez Gene Symbol

PLXNA2

Gene Synonym

FLJ11751FLJ30634KIAA0463OCTPLXN2

Gene Description

Plexin A2

Chromosome

Position

208022242-208244384

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBergmann glia

Function & Pathway

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PLXNA2	FYN	P06241	Y	1,677	phosphorylation	PhosphoSite
PLXNA2	FYN	P06241	Y	1,605	phosphorylation	PhosphoSite
PLXNA2	PRKCA	P17252	S	1,623	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

52 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SEM3B	Q13214	PLXA2	O75051	Yes	Yes	No	SIGNOR	SIGNOR:25335892
SEM3C	Q99985	PLXA2	O75051	Yes	Yes	No	SIGNOR	SIGNOR:19666519
SEM3A	Q14563	PLXA2	O75051	Yes	Yes	No	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACEHPMR_talklr	CellTalkDB:10934324 SIGNOR:10679438 LRdb:10934324
FYN	P06241	PLXA2	O75051	Yes	No	No	Sparser_ProtMapperPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:29091353 ProtMapper:29091353

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PLXNA2-RANBPM complex	PLXNA2 RANBP9	O75051 Q96S59	1:1	CompleatCORUM	CORUM:5758Compleat:HC1112	16672672
	LACRT LCN1 PLXNA2	O75051 P31025 Q9GZZ8	0:0:0	hu.MAP2

Isolation & Detection Technology

0 records.

Sequence, Structure & Domains

Sequences

Length

1,894

Mass

211,104

Sequence

MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75051-1; Sequence=Displayed; Name=2; IsoId=O75051-2; Sequence=VSP_017967, VSP_017968, VSP_017969

Alternative Sequence

1; M -> MGTLGQASLFAPPGNYFWSDHSALCFAESCEGQPGKVEQMSTHRSRLLTAAPLSM (in isoform 2); 458..498; IRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVM -> VRVYEFRCSNAIHLLSKESLLEGSYWWRFNYRQLYFLGEQR (in isoform 2); 499..1894; Missing (in isoform 2)

3D Structural Models

Turn

1558..1560

Helix

1525..1536; 1548..1550; 1584..1587

Beta Strand

1499..1504; 1515..1520; 1551..1557; 1561..1565; 1567..1569; 1594..1599

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Coiled Coil

1261..1310

Domain (FT)

35..508; Sema; 858..951; IPT/TIG 1; 954..1037; IPT/TIG 2; 1041..1139; IPT/TIG 3; 1143..1228; IPT/TIG 4

Protein Families

Plexin family

Sequence Similarities

Belongs to the plexin family.

Clinical Relevance

Antibody

CAB009763