Protein detail
ADA23
Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3)
Entry name ADA23 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3)
Protein Class (3)
Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function (2)
- Predicted secreted proteins
- Predicted intracellular proteins
Transmembrane
793..813; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
ADAM metallopeptidase domain 23
Chromosome
2
Position
206443532-206621127
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway6
Protein Function (2)
- Predicted secreted proteins
- Predicted intracellular proteins
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence36
Ligand-Receptor Signaling (35)
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellCellInteractions | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
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Sequence, Structure & Domains9
Sequences
Length
832
Mass
91,926
Sequence
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=Alpha; IsoId=O75077-1; Sequence=Displayed; Name=Beta; IsoId=O75077-2; Sequence=VSP_012046; Name=Gamma; IsoId=O75077-3; Sequence=VSP_012045
Alternative Sequence
787..832; GPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI -> EMSRREGSILLSKAPSESAALDGHRLALLDSGYDILAAVLLELLSL (in isoform Gamma); 787..817; GPSATNLIIGSIAGAILVAAIVLGGTGWGFK -> VNMATSRLIGAVAGTLLALGVIFGGTGWGIE (in isoform Beta)
Domain & Motif Annotations
Compositional Bias
1..10; Polar residues; 28..37; Low complexity
Domain (CC)
A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
Domain (FT)
299..496; Peptidase M12B; 502..588; Disintegrin; 732..769; EGF-like
Region
1..37; Disordered; 563..568; May bind the integrin receptor
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 31414377 | Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics. | No abstract available |