Protein detail

WDR1

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Entry name WDR1	UniProt ID O75083	EVMP confidence score 0.63
Supporting publications (n) 49	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Protein Class (5)

Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Ensembl

ENSG00000071127

Entrez Gene Symbol

WDR1

Gene Synonym

AIP1

Gene Description

WD repeat domain 1

Chromosome

Position

10068089-10116972

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity

Function & Pathway

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Cellular Component (10)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence65

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter
ecm	ecm	MatrixDB	Yes
ecm	ecm	OmniPath	Yes
extracellular	extracellular	OmniPath
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Protein Complex Composition (56)

56 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BOP1 EIF6 NIP7 NSA2 PA2G4 PES1 RPL23 RPL5 RPLP0 RRP1B RSL1D1 UBC WDR12	O00541 O76021 O95478 P05388 P0CG48 P46777 P56537 P62829 Q14137 Q14684 Q9GZL7 Q9UQ80 Q9Y221	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4252
BOP1 BRIX1 EIF6 GTPBP4 NOP16 NSA2 PES1 RRP1B RSL1D1 RSL24D1 UBC WDR12 WDR74	O00541 O76021 O95478 P0CG48 P56537 Q14137 Q14684 Q6RFH5 Q8TDN6 Q9BZE4 Q9GZL7 Q9UHA3 Q9Y3C1	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7863
BOP1 BRIX1 DDX18 DDX54 EBNA1BP2 EIF6 FTSJ3 GNL3 GTPBP4 LLPH MRTO4 NIFK NIP7 NOC2L NOC3L NOP16 NOP2 NSA2 PES1 RPL10A RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL23 RPL23A RPL26 RPL27 RPL27A RPL28 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL37 RPL4 RPL6 RPL7 RPL7A RPL7L1 RPL9P8 RRS1 RSL1D1 RSL24D1 WDR12 WDR55	O00541 O76021 O95478 P18077 P18124 P18621 P26373 P30050 P32969 P36578 P39023 P40429 P42766 P46087 P46776 P46778 P46779 P49207 P50914 P56537 P61254 P61313 P61353 P61927 P62424 P62750 P62829 P62888 P62899 P62906 P62910 P84098 Q02543 Q02878 Q07020 Q14137 Q15050 Q6DKI1 Q8IY81 Q8TDD1 Q8TDN6 Q8WTT2 Q99848 Q9BRT6 Q9BVP2 Q9BYG3 Q9BZE4 Q9GZL7 Q9H6Y2 Q9NVP1 Q9UHA3 Q9UKD2 Q9Y221 Q9Y3C1 Q9Y3T9 Q9Y3U8	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:8fky
BOP1 EIF6 GTPBP4 LIG3 MAK16 NOP16 NOP2 NSA2 PES1 RRP1B RSL1D1 RSL24D1 SLIRP WDR12 WDR74	O00541 O76021 O95478 P46087 P49916 P56537 Q14137 Q14684 Q6RFH5 Q9BXY0 Q9BZE4 Q9GZL7 Q9GZT3 Q9UHA3 Q9Y3C1	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4939
BOP1 EBNA1BP2 GNL3 GTPBP4 H2AC15 NOP2 PES1 RBM28 RRP1B RSL1D1 SUMO1 UBC WDR12 WDR74	O00541 O76021 P0C0S8 P0CG48 P46087 P63165 Q14137 Q14684 Q6RFH5 Q99848 Q9BVP2 Q9BZE4 Q9GZL7 Q9NW13	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8142
BOP1 GNL3 GTPBP4 MDN1 NOP2 PES1 RBM28 RRP1B RSL1D1 SUMO1 SUMO2 TEX10 UBC WDR12 WDR18	O00541 O76021 P0CG48 P46087 P61956 P63165 Q14137 Q14684 Q9BV38 Q9BVP2 Q9BZE4 Q9GZL7 Q9NU22 Q9NW13 Q9NXF1	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6963
BOP1 CSNK2A1 DDX18 DDX54 NOP2 PES1 PPAN RBM28 RPL5 RRP1B RSL1D1 SLIRP SS18 WDR12 WDR74	O00541 O76021 P46087 P46777 P68400 Q14137 Q14684 Q15532 Q6RFH5 Q8TDD1 Q9GZL7 Q9GZT3 Q9NQ55 Q9NVP1 Q9NW13	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3874
BOP1 FBL GTPBP4 MDN1 NOP2 PELP1 PES1 RBM28 SENP3 SUMO1 SUMO2 TEX10 UBC WDR12 WDR18	O00541 P0CG48 P22087 P46087 P61956 P63165 Q14137 Q8IZL8 Q9BV38 Q9BZE4 Q9GZL7 Q9H4L4 Q9NU22 Q9NW13 Q9NXF1	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6194
BOP1 CEBPZ CTCF EIF6 GTPBP4 NOC3L PA2G4 PES1 PNPLA6 RPL3 UBC WDR12 WDR74	O00541 P0CG48 P39023 P49711 P56537 Q03701 Q14137 Q6RFH5 Q8IY17 Q8WTT2 Q9BZE4 Q9GZL7 Q9UQ80	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9519
BOP1 GTPBP4 LAS1L MDN1 PELP1 PES1 SENP3 SUMO1 SUMO2 TEX10 UBC WDR12 WDR18	O00541 P0CG48 P61956 P63165 Q14137 Q8IZL8 Q9BV38 Q9BZE4 Q9GZL7 Q9H4L4 Q9NU22 Q9NXF1 Q9Y4W2	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8828

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38071653

Sequence, Structure & Domains

Sequences

Length

606

Mass

66,194

Sequence

MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926

Alternative Sequence

47..186; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13

Protein Families

WD repeat AIP1 family

Sequence Similarities

Belongs to the WD repeat AIP1 family.

Clinical Relevance

Disease Involvement

Disease variant

Antibody (3)

CAB020804 HPA036434 HPA070293

Interaction Protein (2)

ENSG00000075624ENSG00000184009

Interaction Count

Interaction Dataset (2)

intact_biogrid_opencellbiogrid_opencell

Supporting Publications49

PMID	Title	Related sentences
35119778	Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.	No related sentences available
35763629	Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers.	No related sentences available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No related sentences available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No related sentences available
36497184	Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.	No related sentences available
36736734	Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus.	No related sentences available
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No related sentences available
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No related sentences available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No related sentences available
37438638	Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy.	No related sentences available

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