Protein detail

WDR1

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Protein symbol WDR1	UniProt ID O75083	EVMP score 0.75
Frequency 50	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Protein Class

Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Ensembl

ENSG00000071127

Entrez Gene Symbol

WDR1

Gene Synonym

AIP1

Gene Description

WD repeat domain 1

Chromosome

Position

10068089-10116972

Frequency

EVMP Score

0.75

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

56 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BOP1 BRD2 H1-6 PES1 WDR12	O00541 P22492 P25440 Q14137 Q9GZL7	0:0:0:0:0	hu.MAP2
BOP1 H1-6 MRTO4 PES1 RSL24D1 WDR12	O00541 P22492 Q14137 Q9GZL7 Q9UHA3 Q9UKD2	0:0:0:0:0:0	hu.MAP2
BOP1 GTPBP4 LAS1L MDN1 NOL9 PELP1 PES1 SENP3 SUMO1 SUMO2 TEX10 WDR18	O00541 P61956 P63165 Q14137 Q5SY16 Q8IZL8 Q9BV38 Q9BZE4 Q9H4L4 Q9NU22 Q9NXF1 Q9Y4W2	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4925
BOP1 GTPBP4 MDN1 PELP1 PES1 PIAS4 SENP3 SUMO1 SUMO2 TEX10 WDR12 WDR18	O00541 P61956 P63165 Q14137 Q8IZL8 Q8N2W9 Q9BV38 Q9BZE4 Q9GZL7 Q9H4L4 Q9NU22 Q9NXF1	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4894
CSNK2A1 DDX18 EBNA1BP2 NOP2 NOP56 NOP58 PPAN RBM28 RPL5 RRP1B RSL1D1 SLIRP SS18 WDR12 WDR74	O00567 O76021 P46087 P46777 P68400 Q14684 Q15532 Q6RFH5 Q99848 Q9GZL7 Q9GZT3 Q9NQ55 Q9NVP1 Q9NW13 Q9Y2X3	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6262
BOP1 CSNK2A1 DDX54 GNL3 NIP7 NOP2 NVL PUM3 RBM28 RPL5 RRP1B RSL1D1 SS18 WDR12 WDR74	O15381 O76021 P46087 P46777 P68400 Q14137 Q14684 Q15397 Q15532 Q6RFH5 Q8TDD1 Q9BVP2 Q9GZL7 Q9NW13 Q9Y221	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9225
ABAT FH HSD17B14 SOD1 TPI1 WDR1	O75083 P00441 P07954 P60174 P80404 Q9BPX1	0:0:0:0:0:0	hu.MAP
ADSL TXNDC17 TYMS UBE2K WDR1 WDR45B ZFYVE21	O75083 P04818 P30566 P61086 Q5MNZ6 Q9BQ24 Q9BRA2	0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_528
FH TPI1 WDR1	O75083 P07954 P60174	0:0:0	hu.MAP
HIBADH WDR1	O75083 P31937	0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38071653

Sequence, Structure & Domains

Sequences

Length

606

Mass

66,194

Sequence

MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926

Alternative Sequence

47..186; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Repeat

4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13

Protein Families

WD repeat AIP1 family

Sequence Similarities

Belongs to the WD repeat AIP1 family.

Clinical Relevance

Disease Involvement

Disease variant

Antibody

CAB020804 HPA036434 HPA070293

Interaction Protein

ENSG00000075624ENSG00000184009

Interaction Count

Interaction Dataset

intact_biogrid_opencellbiogrid_opencell