Protein detail

WDR1

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Entry name
WDR1
UniProt ID
O75083
EVMP confidence score
0.75
Supporting publications (n)
50
Transmembrane count
Protein classification
Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
Protein Class (5)
Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Immune system diseases:Other immune system diseases
  • Predicted intracellular proteins
Ensembl
ENSG00000071127
Entrez Gene Symbol
WDR1
Gene Synonym
AIP1
Gene Description
WD repeat domain 1
Chromosome
4
Position
10068089-10116972
Supporting publications (n)
50
EVMP confidence score
0.75
Fluorescence & Localization7
WDR1 fluorescence
Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity
Function & Pathway6
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Immune system diseases:Other immune system diseases
  • Predicted intracellular proteins
Cellular Component (10)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence65

Ligand-Receptor Signaling (8)

8 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYesNoNoNoNo
ecmecmOmniPathYesNoNoNoNo
extracellularextracellularOmniPathNoNoNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Protein Complex Composition (56)

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Size Exclusion ChromatographyMass spectrometry138071653
Sequence, Structure & Domains8

Sequences

Length
606
Mass
66,194
Sequence
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926
Alternative Sequence
47..186; Missing (in isoform 2)

Domain & Motif Annotations

Repeat
4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13
Protein Families
WD repeat AIP1 family
Sequence Similarities
Belongs to the WD repeat AIP1 family.
Clinical Relevance5
Disease Involvement
Disease variant
Antibody (3)
CAB020804HPA036434HPA070293
Interaction Protein (2)
ENSG00000075624ENSG00000184009
Interaction Count
2
Interaction Dataset (2)
intact_biogrid_opencellbiogrid_opencell
Supporting Publications49
PMIDTitleAbstract
25755179Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease.No abstract available
26826536[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].No abstract available
27086912Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein.No abstract available
27821849Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.No abstract available
28680152Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity.No abstract available
30915084Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.No abstract available
31382537An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.No abstract available
31805958Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.No abstract available
32230970Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.No abstract available
32560723T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.No abstract available
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