Protein detail
WDR1
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
Protein symbol WDR1 | UniProt ID | EVMP score 0.75 |
Frequency 50 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
Protein Class
Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
AIP1
Gene Description
WD repeat domain 1
Chromosome
4
Position
10068089-10116972
Frequency
50
EVMP Score
0.75
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
56 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| EEF1AKMT3IFT122IFT140IFT43IFTAPWDR19WDR35 | Q86VG3Q8NEZ3Q96AZ1Q96FT9Q96RY7Q9HBG6Q9P2L0 | 0:0:0:0:0:0:0 | hu.MAP | |||
| IFT122IFT140IFT43IFTAPWDR19WDR35 | Q86VG3Q8NEZ3Q96FT9Q96RY7Q9HBG6Q9P2L0 | 0:0:0:0:0:0 | hu.MAP2 | |||
| PELP1WDR18 | Q8IZL8Q9BV38 | 2:2 | PDB | PDB:9duoPDB:7uwf | ||
| IFT122IFT140WDR19 | Q8NEZ3Q96RY7Q9HBG6 | 1:1:1 | PDB | PDB:8bbf | ||
| IFT122WDR19 | Q8NEZ3Q9HBG6 | 0:0 | hu.MAP | |||
| WDR12 | Q9GZL7 | 2 | PDB | PDB:6p0qPDB:6n31 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38071653 |
Sequence, Structure & Domains
Sequences
Length
606
Mass
66,194
Sequence
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926
Alternative Sequence
47..186; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Repeat
4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13
Protein Families
WD repeat AIP1 family
Sequence Similarities
Belongs to the WD repeat AIP1 family.