Protein detail

WDR1

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Entry name WDR1	UniProt ID O75083	EVMP confidence score 0.63
Supporting publications (n) 49	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Protein Class (5)

Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Ensembl

ENSG00000071127

Entrez Gene Symbol

WDR1

Gene Synonym

AIP1

Gene Description

WD repeat domain 1

Chromosome

Position

10068089-10116972

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity

Function & Pathway

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Cellular Component (10)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence65

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter
ecm	ecm	MatrixDB	Yes
ecm	ecm	OmniPath	Yes
extracellular	extracellular	OmniPath
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Protein Complex Composition (56)

56 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
EEF1AKMT3 IFT122 IFT140 IFT43 IFTAP WDR19 WDR35	Q86VG3 Q8NEZ3 Q96AZ1 Q96FT9 Q96RY7 Q9HBG6 Q9P2L0	0:0:0:0:0:0:0	hu.MAP
IFT122 IFT140 IFT43 IFTAP WDR19 WDR35	Q86VG3 Q8NEZ3 Q96FT9 Q96RY7 Q9HBG6 Q9P2L0	0:0:0:0:0:0	hu.MAP2
PELP1 WDR18	Q8IZL8 Q9BV38	2:2	PDB	PDB:9duoPDB:7uwf
IFT122 IFT140 WDR19	Q8NEZ3 Q96RY7 Q9HBG6	1:1:1	PDB	PDB:8bbf
IFT122 WDR19	Q8NEZ3 Q9HBG6	0:0	hu.MAP
WDR12	Q9GZL7	2	PDB	PDB:6p0qPDB:6n31

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38071653

Sequence, Structure & Domains

Sequences

Length

606

Mass

66,194

Sequence

MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926

Alternative Sequence

47..186; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13

Protein Families

WD repeat AIP1 family

Sequence Similarities

Belongs to the WD repeat AIP1 family.

Clinical Relevance

Disease Involvement

Disease variant

Antibody (3)

CAB020804 HPA036434 HPA070293

Interaction Protein (2)

ENSG00000075624ENSG00000184009

Interaction Count

Interaction Dataset (2)

intact_biogrid_opencellbiogrid_opencell

Supporting Publications49

PMID	Title	Related sentences
39001700	Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.	No related sentences available
39207047	The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.	No related sentences available
40465195	Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.	No related sentences available
40691760	Comparative Analysis of Platelet-Derived Extracellular Vesicle Protein Extraction Methodologies for Mass Spectrometry.	No related sentences available
40831280	Syntenin Controls Extracellular Vesicle-Induced Tumour Migration by Regulating the Expression of Adhesion Proteins on Small Extracellular Vesicles.	No related sentences available
40840701	Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.	No related sentences available
40985879	TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.	No related sentences available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No related sentences available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No related sentences available

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