Protein detail

WDR1

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Entry name WDR1	UniProt ID O75083	EVMP confidence score 0.75
Supporting publications (n) 50	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Protein Class (5)

Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Ensembl

ENSG00000071127

Entrez Gene Symbol

WDR1

Gene Synonym

AIP1

Gene Description

WD repeat domain 1

Chromosome

Position

10068089-10116972

Supporting publications (n)

EVMP confidence score

0.75

Fluorescence & Localization7

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity

Function & Pathway6

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Cellular Component (10)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence65

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (56)

56 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
5FMC (Friends of Methylated Chtop) complex	LAS1L PELP1 SENP3 TEX10 WDR18	Q8IZL8 Q9BV38 Q9H4L4 Q9NXF1 Q9Y4W2	0:0:0:0:0	CORUM	CORUM:6854	22872859
DDX27-PeBoW complex	BOP1 DDX27 PES1 WDR12	O00541 Q14137 Q96GQ7 Q9GZL7	0:0:0:0	CORUM	CORUM:6306	25825154
HT_DM_Cluster212	BRWD1 BRWD3 DDB1 DTL PHIP WDR17	Q16531 Q6RI45 Q8IZU2 Q8WWQ0 Q9NSI6 Q9NZJ0	1:1:1:1:1:1	Compleat	Compleat:HC3530	22036573
HT_DM_Cluster38	BOP1 EIF6 GTPBP4 MAK16 MRPL2 PES1 RRP1 RRP1B WDR12 WDR74	O00541 P56182 P56537 Q14137 Q14684 Q5T653 Q6RFH5 Q9BXY0 Q9BZE4 Q9GZL7	1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2477	22036573
Intraflagellar transport complex A	IFT122 IFT140 IFT43 TTC21B WDR19 WDR35	Q7Z4L5 Q8NEZ3 Q96FT9 Q96RY7 Q9HBG6 Q9P2L0	1:1:1:1:1:1	ComplexPortalPDB	PDB:8fgwintact:EBI-22224236PDB:8bbg	27806291 23945166 29272450 14755292 26498262 22118932
Intraflagellar transport complex A	IFT122 IFT140 TTC21B WDR19 WDR35	Q7Z4L5 Q8NEZ3 Q96RY7 Q9HBG6 Q9P2L0	0:0:0:0:0	CORUM	CORUM:6585	20889716
LAS1L-PELP1-TEX10-WDR18-NOL9-SENP3 complex	LAS1L NOL9 PELP1 SENP3 TEX10 WDR18	Q5SY16 Q8IZL8 Q9BV38 Q9H4L4 Q9NXF1 Q9Y4W2	0:0:0:0:0:0	CORUMhu.MAPhu.MAP2	CORUM:6855	22190735
PELP1-TEX10-WDR18 complex	PELP1 TEX10 WDR18	Q8IZL8 Q9BV38 Q9NXF1	2:2:2	CORUMhu.MAP2PDB	CORUM:6857PDB:9dum	21326211
PeBoW complex	BOP1 PES1 WDR12	O00541 Q14137 Q9GZL7	1:1:1	CORUMComplexPortalCompleathu.MAP2CFinder	intact:EBI-9026844CORUM:6856Compleat:HC3045Compleat:HC1392	16043514 14755292 12110181 24120868 17353269
Rix1 complex	NOL9 PELP1 SENP3 TEX10 WDR18	Q5SY16 Q8IZL8 Q9BV38 Q9H4L4 Q9NXF1	0:0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C373

Page 1 of 6Next

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38071653

Sequence, Structure & Domains8

Sequences

Length

606

Mass

66,194

Sequence

MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926

Alternative Sequence

47..186; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13

Protein Families

WD repeat AIP1 family

Sequence Similarities

Belongs to the WD repeat AIP1 family.

Clinical Relevance5

Disease Involvement

Disease variant

Antibody (3)

CAB020804 HPA036434 HPA070293

Interaction Protein (2)

ENSG00000075624ENSG00000184009

Interaction Count

Interaction Dataset (2)

intact_biogrid_opencellbiogrid_opencell

Supporting Publications49

PMID	Title	Abstract
35119778	Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.	No abstract available
35763629	Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
36497184	Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.	No abstract available
36736734	Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus.	No abstract available
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No abstract available
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
37438638	Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy.	No abstract available

Page 3 of 5Previous Next