Protein detail

LRP4

Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)

Entry name LRP4	UniProt ID O75096	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)

Protein Class (6)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (6)

Transporters
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Predicted intracellular proteins
Potential drug targets
Disease related genes

Transmembrane

1726..1746; Helical

Transmembrane Count

Ensembl

ENSG00000134569

Entrez Gene Symbol

LRP4

Gene Synonym (4)

CLSSLRP-4MEGF7SOST2

Gene Description

LDL receptor related protein 4

Chromosome

Position

46856717-46918642

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificleukocyte

Function & Pathway7

Protein Function (6)

Transporters
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Predicted intracellular proteins
Potential drug targets
Disease related genes

Cellular Component (8)

Molecular Function (7)

Biological Process (3)

Reactome (2)

Canonical Pathways

M211 Pid hedgehog 2pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence49

Ligand-Receptor Signaling (42)

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LRP4	O75096	MUSK	O15146	Yes	Yes	No	HINTSIGNOR	HINT:37252960 SIGNOR:23458718
AGRIN	O00468	LRP4	O75096	Yes	Yes	No	Fantom5_LRdbCellTalkDBiTALKtalklrSIGNORReactome_LRdbconnectomeDB2020HINTCellinkerLRdbRamilowski2015	SIGNOR:23458718 Cellinker:18848351 LRdb:18848351 HINT:37252960 Ramilowski2015:18848351 talklr:18848351 connectomeDB2020:18848351
SDF2L	Q9HCN8	LRP4	O75096	Yes	Yes	No	SIGNOR	SIGNOR:24140340

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BEND7 LRP4 RPS28	O75096 P62857 Q8N7W2	0:0:0	hu.MAP
NLRP4 YTHDF1 YTHDF2 YTHDF3	Q7Z739 Q96MN2 Q9BYJ9 Q9Y5A9	0:0:0:0	hu.MAP2
NLRP4	Q96MN2	2	PDB	PDB:4ewi

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	31414377

Sequence, Structure & Domains11

Sequences

Length

1,905

Mass

212,045

Sequence

MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

1676..1686; Low complexity; 1882..1905; Basic and acidic residues

Repeat

480..522; LDL-receptor class B 1; 523..565; LDL-receptor class B 2; 566..609; LDL-receptor class B 3; 610..652; LDL-receptor class B 4; 653..693; LDL-receptor class B 5; 785..827; LDL-receptor class B 6; 828..870; LDL-receptor class B 7; 871..914; LDL-receptor class B 8; 915..956; LDL-receptor class B 9; 957..998; LDL-receptor class B 10; 1093..1135; LDL-receptor class B 11; 1136..1178; LDL-receptor class B 12; 1179..1222; LDL-receptor class B 13; 1223..1263; LDL-receptor class B 14; 1264..1306; LDL-receptor class B 15; 1397..1439; LDL-receptor class B 16; 1440..1482; LDL-receptor class B 17; 1483..1526; LDL-receptor class B 18; 1527..1568; LDL-receptor class B 19; 1569..1610; LDL-receptor class B 20

Motif

1766..1769; Endocytosis signal

Domain (FT)

26..67; LDL-receptor class A 1; 70..106; LDL-receptor class A 2; 109..144; LDL-receptor class A 3; 147..183; LDL-receptor class A 4; 190..226; LDL-receptor class A 5; 230..266; LDL-receptor class A 6; 269..305; LDL-receptor class A 7; 311..350; LDL-receptor class A 8; 354..394; EGF-like 1; calcium-binding; 395..434; EGF-like 2; calcium-binding; 698..737; EGF-like 3

Region

1659..1686; Disordered; 1852..1905; Disordered

Protein Families

LDLR family

Sequence Similarities

Belongs to the LDLR family.

Clinical Relevance2

Disease Involvement (2)

Congenital myasthenic syndromeDisease variant

Antibody (2)

HPA011934 HPA012300

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available