Protein detail
MFA3L
Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9)
Entry name MFA3L | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
150..172; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
KIAA0626NYD-sp9
Gene Description
Microfibril associated protein 3 like
Chromosome
4
Position
169986597-170033031
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function
Biological Process (3)
Canonical Pathways
M16801 Sig regulation of the actin cytoskeleton by rho gtpases
Mediation Categories
Other mediation
Relations & Evidence28
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MFAP3L | EGFR | P00533 | Y | 287 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:24735981 |
Ligand-Receptor Signaling (26)
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | Yes | |||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | UniProt_location | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | ||
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | ||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes |
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Sequence, Structure & Domains
Sequences
Length
409
Mass
45,380
Sequence
MDRLKSHLTVCFLPSVPFLILVSTLATAKSVTNSTLNGTNVVLGSVPVIIARTDHIIVKEGNSALINCSVYGIPDPQFKWYNSIGKLLKEEEDEKERGGGKWQMHDSGLLNITKVSFSDRGKYTCVASNIYGTVNNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMVLNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAADRDEVYTIPNSLKRSDSPAADSDASSLHEQPQQIAIKVSVHPQSKKEHADDQEGGQFEVKDVEETELSAEHSPETAEPSTDVTSTELTSEEPTPVEVPDKVLPPAYLEATEPAVTHDKNTCIIYESHV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75121-1; Sequence=Displayed; Name=2; IsoId=O75121-2; Sequence=VSP_011100; Name=3; IsoId=O75121-3; Sequence=VSP_014094, VSP_014095
Alternative Sequence
1..103; Missing (in isoform 2); 101..102; KW -> RL (in isoform 3); 103..409; Missing (in isoform 3)
Domain & Motif Annotations
Compositional Bias
339..355; Basic and acidic residues; 363..377; Low complexity
Domain (FT)
47..141; Ig-like C2-type
Region
292..311; Disordered; 320..385; Disordered
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 40222457 | Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement. | No related sentences available |