Protein detail

COBL

Protein cordon-bleu

Entry name COBL	UniProt ID O75128	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein cordon-bleu

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000106078

Entrez Gene Symbol

COBL

Gene Synonym

KIAA0633

Gene Description

Cordon-bleu WH2 repeat protein

Chromosome

Position

51016212-51316818

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificCardiomyocytes

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (12)

Page 1 of 2

Molecular Function (2)

Biological Process (3)

Canonical Pathways (3)

M1315 Sig pip3 signaling in b lymphocytes
M8626 Sig bcr signaling pathway
M7955 Sig insulin receptor pathway in cardiac myocytes

Mediation Categories

Fusion and delivery mediation

Relations & Evidence8

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CCDC198 COBL GC	O75128 P02774 Q9NVL8	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingELISA	3	38731868 40619995 40784529

Sequence, Structure & Domains11

Sequences

Length

1,261

Mass

135,617

Sequence

MDAPRASAAKPPTGRKMKARAPPPPGKAATLHVHSDQKPPHDGALGSQQNLVRMKEALRASTMDVTVVLPSGLEKRSVLNGSHAMMDLLVELCLQNHLNPSHHALEIRSSETQQPLSFKPNTLIGTLNVHTVFLKEKVPEEKVKPGPPKVPEKSVRLVVNYLRTQKAVVRVSPEVPLQNILPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRRETFRKSSLGNDETDKEKKKFLGFFKVNKRSNSKGCLTTPNSPSMHSRSLTLGPSLSLGSISGVSVKSEMKKRRAPPPPGSGPPVQDKASEKVSLGSQIDLQKKKRRAPAPPPPQPPPPSPLIPNRTEDKEENRKSTMVSLPLGSGSHCSPDGAPQVLSEAEETVSVGSCFASEDTTEDSGVMSSPSDIVSLDSQQDSMKYKDKWATDQEDCSDQDLAGTPDLGPQKSPLWEKNGSENSHLRTEKAVTASNDEEDLLIAGEFRKTLAELDEDLEEMEDSYETDTSSLTSSIHGASNHCPQDAMIPHGDTDAIPVTFIGEVSDDPVDSGLFSNRNNNAGSFDSEGVASRRDSLAPLQAEHSQPHEKAREEVPALHPASHDVGKGIRVALSNISKDGNLMETAPRVTSFASNLHTDNLNAKVKDKVYGCADGERTQATERVNSQPVNEKDSNDKNAALAPTSWHQRGQNPGKSYRLKHGLTTYKIIPPKSEMRCYDRDVSLSTGAIKIDELGNLVSPHATGIRIISLSSSVPEAESQPIGKVREFWRCNSVEKHLGRPSESSARGPPSTPVPTQTQNPESRLQADPKPISPQQKSAHHEGRNPLGEGRNQPPTMGMGHVRVPAAHTTEVTFLKPQRRTSSQYVASAIAKRIGAPKVHADVVRPHGYAEKGYAGKAPVLAAPPVTVKDDRTSSPHSETQGWKDGAQWPCVTPPNNHGEDLAVGAPPRGEVIGPHRKLSTQDRPAAIHRSSCFSLVQSSQRDRVSVGQSCGFSGKQSTSSQEASSASEPRRAPDGTDPPPPHTSDTQACSRELVNGSVRAPGHGEPSHPPGGSGTESHILLEREEKPSVFSTDGNETDSIWPPSIFGPKKKFKPVVQRPVPKDTSLHSALMEAIHSAGGKDRLRKTAEHTGEGRPAKLSYTEAEGERSALLAAIRGHSGTCSLRKVASSASEELQSFRDAALSAQGSESPLLEDLGLLSPPAIPPPPPPPSQALSAPRTASRFSTGTLSNTADARQALMDAIRSGTGAARLRKVPLLV

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=O75128-1; Sequence=Displayed; Name=2; IsoId=O75128-2; Sequence=VSP_021607, VSP_021608; Name=3; IsoId=O75128-3; Sequence=VSP_021613; Name=4; IsoId=O75128-4; Sequence=VSP_021609, VSP_021612; Name=5; IsoId=O75128-5; Sequence=VSP_021610, VSP_021611; Name=6; IsoId=O75128-6; Sequence=VSP_040711, VSP_040712; Name=7; IsoId=O75128-7; Sequence=VSP_021608, VSP_021613

Alternative Sequence

1..458; Missing (in isoform 6); 261; K -> KAEQLVLSGADSDEDTSRAAPGRGLN (in isoform 2); 366; V -> GGGRQVPQKPPRGTARGPPQLVLPPPPPYPPPDTDVVEPLSFPGEGAGSEASDPIPKL (in isoform 2 and isoform 7); 367..469; SLPLGSGSHCSPDGAPQVLSEAEETVSVGSCFASEDTTEDSGVMSSPSDIVSLDSQQDSMKYKDKWATDQEDCSDQDLAGTPDLGPQKSPLWEKNGSENSHLR -> YGAAEAVIRLLSLLLNTTAPGTAKPRTLWMSEGRSSLHNPEIKCSCFSSSSPFPQSLLSLLLGLSSICECMCTLRHTHAHTHNPSCVLPTSEILAFGRQSLIS (in isoform 4); 367..379; SLPLGSGSHCSPD -> YCCASFPTQAKRF (in isoform 5); 380..1261; Missing (in isoform 5); 459..468; EKNGSENSHL -> MSAPFSLVFP (in isoform 6); 470..1261; Missing (in isoform 4); 1169..1215; Missing (in isoform 3 and isoform 7)

3D Structural Models

Helix

1114..1118; 1123..1125

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

260..273; Polar residues; 274..294; Low complexity; 336..349; Pro residues; 353..362; Basic and acidic residues; 409..425; Polar residues; 509..520; Polar residues; 587..600; Basic and acidic residues; 687..696; Polar residues; 796..805; Polar residues; 989..998; Polar residues; 999..1010; Low complexity; 1072..1081; Polar residues; 1121..1138; Basic and acidic residues; 1204..1214; Pro residues

Motif

298..303; KKRRAP 1; 331..336; KKRRAP 2

Domain (FT)

1109..1129; WH2 1; 1149..1169; WH2 2; 1237..1257; WH2 3

Region

1..46; Disordered; 259..480; Disordered; 500..534; Disordered; 580..600; Disordered; 658..699; Disordered; 779..843; Disordered; 907..1104; Disordered; 1120..1145; Disordered; 1196..1232; Disordered

Clinical Relevance4

Antibody (2)

HPA019033 HPA019167

Interaction Protein (3)

ENSG00000100266ENSG00000124507ENSG00000165912

Interaction Count

Interaction Dataset (3)

intact_biogrid_opencellintact_biogridbiogrid_opencell

Supporting Publications2

PMID	Title	Abstract
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40985879	TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.	No abstract available