Protein detail
AT2C2
Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2)
Entry name AT2C2 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 10 | Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2)
Protein Class (5)
EnzymesFDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function (4)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
107..127; Helical; Name=1; 130..150; Helical; Name=2; 232..252; Helical; Name=3; 294..314; Helical; Name=4; 332..352; Helical; Name=5; 751..771; Helical; Name=6; 805..825; Helical; Name=7; 838..855; Helical; Name=8; 875..895; Helical; Name=9; 906..926; Helical; Name=10
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
KIAA0703SPCA2
Gene Description
ATPase secretory pathway Ca2+ transporting 2
Chromosome
16
Position
84368527-84464187
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (4)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component (8)
Molecular Function (6)
Biological Process (3)
Reactome (3)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence17
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location |
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Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ATP2C2IARS1PISDPMM2SUMO2UBC | O15305O75185P0CG48P41252P61956Q9UG56 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4656 | ||
| ATP2C2IARS1PISDPMM1RUVBL2UBC | O75185P0CG48P41252Q92871Q9UG56Q9Y230 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5627 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryFlow cytometryMORPH | 1 | 37563857 |
Sequence, Structure & Domains
Sequences
Length
946
Mass
103,169
Sequence
MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75185-1; Sequence=Displayed; Name=2; IsoId=O75185-2; Sequence=VSP_035989; Name=3; IsoId=O75185-3; Sequence=VSP_054679
Alternative Sequence
1..70; MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFC -> MLHFHLLKFKTRVVFSAVIIMVTGLCLFLLSLPHLHGVFEQVPAPWWTSLCPWPIMEAAAFQSGSLYPVASFLAAPMSELVPDLSFQ (in isoform 2); 778; S -> RSSQKTEVCCTAVRLGVEGRGESTWAGRAG (in isoform 3)
Domain & Motif Annotations
Region
71..95; Interaction with ORAI1
Protein Families (2)
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IIA subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |