Protein detail

AT2C2

Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2)

Entry name
AT2C2
UniProt ID
O75185
EVMP confidence score
0.50
Supporting publications (n)
1
Transmembrane count
10
Protein classification
EnzymesFDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2)
Protein Class (5)
EnzymesFDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function (4)
  • Enzymes
  • ENZYME proteins
  • Transporters:Primary Active Transporters
  • FDA approved drug targets:Small molecule drugs
Transmembrane
107..127; Helical; Name=1; 130..150; Helical; Name=2; 232..252; Helical; Name=3; 294..314; Helical; Name=4; 332..352; Helical; Name=5; 751..771; Helical; Name=6; 805..825; Helical; Name=7; 838..855; Helical; Name=8; 875..895; Helical; Name=9; 906..926; Helical; Name=10
Transmembrane Count
10
Ensembl
ENSG00000064270
Entrez Gene Symbol
ATP2C2
Gene Synonym (2)
KIAA0703SPCA2
Gene Description
ATPase secretory pathway Ca2+ transporting 2
Chromosome
16
Position
84368527-84464187
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway6
Protein Function (4)
  • Enzymes
  • ENZYME proteins
  • Transporters:Primary Active Transporters
  • FDA approved drug targets:Small molecule drugs
Cellular Component (8)
Molecular Function (6)
Biological Process (3)
Reactome (3)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence17

Ligand-Receptor Signaling (14)

14 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
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Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ATP2C2IARS1PISDPMM2SUMO2UBCO15305O75185P0CG48P41252P61956Q9UG561:1:1:1:1:1NetworkBlastCompleatCompleat:HC4656
ATP2C2IARS1PISDPMM1RUVBL2UBCO75185P0CG48P41252Q92871Q9UG56Q9Y2301:1:1:1:1:1NetworkBlastCompleatCompleat:HC5627

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryFlow cytometryMORPH137563857
Sequence, Structure & Domains8

Sequences

Length
946
Mass
103,169
Sequence
MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75185-1; Sequence=Displayed; Name=2; IsoId=O75185-2; Sequence=VSP_035989; Name=3; IsoId=O75185-3; Sequence=VSP_054679
Alternative Sequence
1..70; MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFC -> MLHFHLLKFKTRVVFSAVIIMVTGLCLFLLSLPHLHGVFEQVPAPWWTSLCPWPIMEAAAFQSGSLYPVASFLAAPMSELVPDLSFQ (in isoform 2); 778; S -> RSSQKTEVCCTAVRLGVEGRGESTWAGRAG (in isoform 3)

Domain & Motif Annotations

Region
71..95; Interaction with ORAI1
Protein Families (2)
  • Cation transport ATPase (P-type) (TC 3.A.3) family
  • Type IIA subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Clinical Relevance3
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Antibody (2)
HPA052262HPA075812
Supporting Publications1
PMIDTitleAbstract
32384937Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.No abstract available