Protein detail
LRP5
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Entry name LRP5 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Protein Class (4)
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
1385..1407; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (10)
BMND1EVR1EVR4HBMLR3LRP7OPPGOPSOPTA1VBCH2
Gene Description
LDL receptor related protein 5
Chromosome
11
Position
68312591-68449275
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization2
Cell SpecificBreast lactating cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway7
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
KEGG (10)
- hsa04150 mTOR signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04928 Parathyroid hormone synthesis, secretion and action
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
Reactome (9)
- R-hsa-4641262 disassembly of the destruction complex and recruitment of axin to the membrane
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-3772470 negative regulation of tcf dependent signaling by wnt ligand antagonists
- R-hsa-4641263 regulation of fzd by ubiquitination
- R-hsa-5339717 signaling by lrp5 mutants
- R-hsa-5340588 signaling by rnf43 mutants
- R-hsa-195721 signaling by wnt
- R-hsa-4791275 signaling by wnt in cancer
- R-hsa-201681 tcf dependent signaling in response to wnt
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence92
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LRP5 | LRP6 | O75581 | S | 1,503 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:23022962 |
Ligand-Receptor Signaling (52)
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| low_density_lipoprotein | receptor | Almen2009 | No | Yes | No | Yes | No |
| cytokine | receptor | Baccin2019 | No | Yes | No | Yes | No |
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Regulatory Interaction Network (25)
25 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| WNT8A | Q9H1J5 | LRP5 | O75197 | Yes | Yes | No | CellTalkDBSIGNORReactome_LRdbCellinkerLRdbCellCall | SIGNOR:15578921Cellinker:23209147CellTalkDB:32196115 |
| WNT9A | O14904 | LRP5 | O75197 | Yes | Yes | No | CellinkerSIGNORCellCall | Cellinker:23209147SIGNOR:15578921 |
| FZD4 | Q9ULV1 | LRP5 | O75197 | Yes | Yes | No | WangSIGNOR | SIGNOR:25902418 |
| LRP5 | O75197 | COMPLEX:O15169_P25054_P49841 | Yes | No | Yes | SIGNOR | SIGNOR:11336703 | |
| WNT9B | O14905 | LRP5 | O75197 | Yes | Yes | No | CellinkerSIGNORCellCall | Cellinker:23209147SIGNOR:15578921 |
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Protein Complex Composition (13)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31805958 |
Sequence, Structure & Domains10
Sequences
Length
1,615
Mass
179,145
Sequence
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
Domain & Motif Annotations
Compositional Bias
1604..1615; Pro residues
Repeat
75..119; LDL-receptor class B 1; 78..81; YWTD 1; 120..162; LDL-receptor class B 2; 123..126; YWTD 2; 163..206; LDL-receptor class B 3; 166..169; YWTD 3; 207..247; LDL-receptor class B 4; 248..290; LDL-receptor class B 5; 251..254; YWTD 4; 385..427; LDL-receptor class B 6; 388..391; YWTD 5; 428..470; LDL-receptor class B 7; 431..434; YWTD 6; 471..514; LDL-receptor class B 8; 474..477; YWTD 7; 515..557; LDL-receptor class B 9; 558..600; LDL-receptor class B 10; 559..562; YWTD 8; 687..729; LDL-receptor class B 11; 690..693; YWTD 9; 730..772; LDL-receptor class B 12; 773..815; LDL-receptor class B 13; 816..855; LDL-receptor class B 14; 819..822; YWTD 10; 856..898; LDL-receptor class B 15; 859..862; YWTD 11; 989..1035; LDL-receptor class B 16; 1036..1078; LDL-receptor class B 17; 1079..1123; LDL-receptor class B 18; 1124..1164; LDL-receptor class B 19; 1165..1207; LDL-receptor class B 20
Motif
1500..1506; PPPSP motif A; 1538..1545; PPPSP motif B; 1574..1581; PPPSP motif C; 1591..1596; PPPSP motif D; 1605..1612; PPPSP motif E
Domain (FT)
295..337; EGF-like 1; 601..641; EGF-like 2; 902..942; EGF-like 3; 1213..1254; EGF-like 4; 1258..1296; LDL-receptor class A 1; 1297..1333; LDL-receptor class A 2; 1335..1371; LDL-receptor class A 3
Region
32..288; Beta-propeller 1; 341..602; Beta-propeller 2; 644..903; Beta-propeller 3; 945..1212; Beta-propeller 4; 1475..1501; Disordered; 1568..1615; Disordered
Protein Families
LDLR family
Sequence Similarities
Belongs to the LDLR family.
Clinical Relevance7
Disease Involvement (4)
Disease variantOsteogenesis imperfectaOsteopetrosisOsteoporosis
Related Diseases
Biomarker
Phase 1
Interaction Protein (4)
ENSG00000107984ENSG00000110888ENSG00000167941ENSG00000185900
Interaction Count
4
Interaction Dataset (3)
biogrid_bioplexintact_biogridintact_biogrid_bioplex
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |