Protein detail
LRP5
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Protein symbol LRP5 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
1385..1407; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
BMND1EVR1EVR4HBMLR3LRP7OPPGOPSOPTA1VBCH2
Gene Description
LDL receptor related protein 5
Chromosome
11
Position
68312591-68449275
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificBreast lactating cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04150 mTOR signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04928 Parathyroid hormone synthesis, secretion and action
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
Reactome
- R-hsa-4641262 disassembly of the destruction complex and recruitment of axin to the membrane
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-3772470 negative regulation of tcf dependent signaling by wnt ligand antagonists
- R-hsa-4641263 regulation of fzd by ubiquitination
- R-hsa-5339717 signaling by lrp5 mutants
- R-hsa-5340588 signaling by rnf43 mutants
- R-hsa-195721 signaling by wnt
- R-hsa-4791275 signaling by wnt in cancer
- R-hsa-201681 tcf dependent signaling in response to wnt
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LRP5 | LRP6 | O75581 | S | 1,503 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:23022962 |
Ligand-Receptor Signaling
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
Regulatory Interaction Network
25 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GSK3B | P49841 | LRP5 | O75197 | Yes | Yes | No | SignaLink3 | SignaLink3:23331499SignaLink3:16341017 |
| FZD8 | Q9H461 | LRP5 | O75197 | Yes | Yes | No | WangNetPathSIGNORHPRDCui2007SPIKE_LCSPIKE | HPRD:11448771SPIKE:11448771NetPath:11448771SPIKE_LC:11448771SIGNOR:21078818 |
| WNT1 | P04628 | LRP5 | O75197 | Yes | Yes | No | iTALKSIGNORHPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019WangRamilowski2015Reactome_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbNetPathSPIKE_LCLRdbSPIKE | HPRD:11336703LRdb:11336703SPIKE_LC:11336703SIGNOR:21078818CellTalkDB:11336703SIGNOR:15578921Baccin2019:11336703NetPath:11336703SPIKE:11336703 |
| LRP5 | O75197 | AXIN1 | O15169 | Yes | Yes | Yes | WangNetPathSIGNORHPRDSignaLink3ACSNSPIKE_LCSPIKE | ACSN:8666229HPRD:11336703NetPath:19075000SPIKE_LC:11336703SIGNOR:11336703SignaLink3:11336703SignaLink3:23331499NetPath:11336703SignaLink3:18632848SPIKE:11336703ACSN:10428961SignaLink3:21071413 |
| TDGF1 | P13385 | LRP5 | O75197 | Yes | Yes | No | SignaLink3 | SignaLink3:23022962 |
| NDP | Q00604 | LRP5 | O75197 | Yes | Yes | No | SignaLink3 | SignaLink3:24186977 |
| KC1G1 | Q9HCP0 | LRP5 | O75197 | Yes | Yes | No | SignaLink3 | SignaLink3:16341016SignaLink3:23331499 |
| FZD5 | Q13467 | LRP5 | O75197 | Yes | Yes | No | WangSIGNOR | SIGNOR:25902418 |
| LRP5 | O75197 | DVL1 | O14640 | Yes | Yes | No | SIGNOR | SIGNOR:23209147 |
| WNT7B | P56706 | LRP5 | O75197 | Yes | Yes | No | HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACECellCallHPMR_talklr | HPMR:15923619Baccin2019:15923619SIGNOR:15578921LRdb:15923619CellTalkDB:15923619SIGNOR:15923619connectomeDB2020:15923619 |
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Protein Complex Composition
13 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FZD2_LRP5 | FZD2LRP5 | O75197Q14332 | 1:1 | CellPhoneDBCellChatDBICELLNET | CellPhoneDB:FZD2_LRP5 | 24032637287334583401783535303793 |
| FZD3_LRP5 | FZD3LRP5 | O75197Q9NPG1 | 1:1 | CellPhoneDBCellChatDBICELLNET | CellPhoneDB:FZD3_LRP5 | 2403263735303793 |
| FZD5_LRP5 | FZD5LRP5 | O75197Q13467 | 1:1 | CellPhoneDBCellChatDBICELLNET | CellPhoneDB:FZD5_LRP5 | 24032637287334583401783535303793 |
| FZD7_LRP5 | FZD7LRP5 | O75084O75197 | 1:1 | CellPhoneDBCellChatDBICELLNET | CellPhoneDB:FZD7_LRP5 | 2997963334017835240326372873345835303793 |
| FZD8_LRP5 | FZD8LRP5 | O75197Q9H461 | 1:1 | CellPhoneDBCellChatDBICELLNET | CellPhoneDB:FZD8_LRP5 | 24032637268499592873345835303793 |
| FZD9_LRP5 | FZD9LRP5 | O00144O75197 | 1:1 | CellPhoneDBCellinkerICELLNETCellChatDB | CellPhoneDB:FZD9_LRP5 | 24032637157055941903897335303793 |
| KHDC3L-NLRP5-OOEP-TLE6 complex | KHDC3LNLRP5OOEPTLE6 | A6NGQ2P59047Q587J8Q9H808 | 0:0:0:0 | CORUM | CORUM:7378 | 25542835 |
| ASPDHNLRP5PFKLPFKPRBKSUGP2 | A6ND91P17858P59047Q01813Q16851Q9H477 | 0:0:0:0:0:0 | hu.MAP2 | |||
| NLRP5OOEPTLE6 | A6NGQ2P59047Q9H808 | 2:2:2 | PDB | PDB:8x7wPDB:8x7v | ||
| LGR5LRP5 | O75197O75473 | 0:0 | Cellinker |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31805958 |
Sequence, Structure & Domains
Sequences
Length
1,615
Mass
179,145
Sequence
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1604..1615; Pro residues
Repeat
75..119; LDL-receptor class B 1; 78..81; YWTD 1; 120..162; LDL-receptor class B 2; 123..126; YWTD 2; 163..206; LDL-receptor class B 3; 166..169; YWTD 3; 207..247; LDL-receptor class B 4; 248..290; LDL-receptor class B 5; 251..254; YWTD 4; 385..427; LDL-receptor class B 6; 388..391; YWTD 5; 428..470; LDL-receptor class B 7; 431..434; YWTD 6; 471..514; LDL-receptor class B 8; 474..477; YWTD 7; 515..557; LDL-receptor class B 9; 558..600; LDL-receptor class B 10; 559..562; YWTD 8; 687..729; LDL-receptor class B 11; 690..693; YWTD 9; 730..772; LDL-receptor class B 12; 773..815; LDL-receptor class B 13; 816..855; LDL-receptor class B 14; 819..822; YWTD 10; 856..898; LDL-receptor class B 15; 859..862; YWTD 11; 989..1035; LDL-receptor class B 16; 1036..1078; LDL-receptor class B 17; 1079..1123; LDL-receptor class B 18; 1124..1164; LDL-receptor class B 19; 1165..1207; LDL-receptor class B 20
Motif
1500..1506; PPPSP motif A; 1538..1545; PPPSP motif B; 1574..1581; PPPSP motif C; 1591..1596; PPPSP motif D; 1605..1612; PPPSP motif E
Domain (FT)
295..337; EGF-like 1; 601..641; EGF-like 2; 902..942; EGF-like 3; 1213..1254; EGF-like 4; 1258..1296; LDL-receptor class A 1; 1297..1333; LDL-receptor class A 2; 1335..1371; LDL-receptor class A 3
Region
32..288; Beta-propeller 1; 341..602; Beta-propeller 2; 644..903; Beta-propeller 3; 945..1212; Beta-propeller 4; 1475..1501; Disordered; 1568..1615; Disordered
Protein Families
LDLR family
Sequence Similarities
Belongs to the LDLR family.
Clinical Relevance
Disease Involvement
Disease variantOsteogenesis imperfectaOsteopetrosisOsteoporosis
Related Diseases
Biomarker
Phase 1
Interaction Protein
ENSG00000107984ENSG00000110888ENSG00000167941ENSG00000185900
Interaction Count
4
Interaction Dataset
biogrid_bioplexintact_biogridintact_biogrid_bioplex