Protein detail
SEM7A
Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)
Entry name SEM7A | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 10 | Transmembrane count | Protein classification Blood group antigen proteinsCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)
Protein Class (6)
Blood group antigen proteinsCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function (4)
- Disease related genes
- Blood group antigen proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- CD markers
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CD108H-Sema-LSEMAL
Gene Description
Semaphorin 7A (John Milton Hagen blood group)
Chromosome
15
Position
74409289-74433958
Supporting publications (n)
10
EVMP confidence score
0.50
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function (4)
- Disease related genes
- Blood group antigen proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- CD markers
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
Reactome (3)
Canonical Pathways (2)
- M137 Pid vegf vegfr pathway
- M274 Pid lymph angiogenesis pathway
Mediation Categories (3)
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence53
Ligand-Receptor Signaling (49)
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | Yes | Yes | ||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | Yes | Yes | ||
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | Yes | Yes | ||
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | Yes | Yes | ||
| semaphorin | cell_surface_ligand | HGNC | Yes | Yes | Yes | ||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | |
| transmembrane | transmembrane | CellPhoneDB | Yes | Yes |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SEM7A | O75326 | PLXC1 | O60486 | Yes | Yes | iTALKICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:10520995InnateDB:20727575LRdb:10520995CellTalkDB:10520995HINT:20727575Baccin2019:1052099510520990HPMR:10520995CellChatDB:27533782Cellinker:26633812Cellinker:27533782IntAct:20727575Lit-BM-17:20727575SIGNOR:10520995HPRD:10520995ICELLNET:10520995ICELLNET:17671519connectomeDB2020:10520995 | |
| SEM7A | O75326 | COMPLEX:P05556_P56199 | Yes | Yes | CellChatDBCellPhoneDBICELLNETSIGNORCellPhoneDB_CellinkerCellinker | Cellinker:22325954Cellinker:30568033SIGNOR:17377534CellChatDB:22325954Cellinker:12879062ICELLNET:17671519 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38315424 |
Sequence, Structure & Domains
Sequences
Length
666
Mass
74,824
Sequence
MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLTLGLLVH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75326-1; Sequence=Displayed; Name=2; IsoId=O75326-2; Sequence=VSP_045349
Alternative Sequence
111..124; Missing (in isoform 2)
3D Structural Models
Turn
62..64; 146..148; 275..279; 294..296; 472..475; 537..540
Helix
235..237; 316..318; 339..348; 375..383; 499..505
Beta Strand
65..68; 77..79; 85..90; 92..99; 110..112; 129..136; 139..144; 151..158; 160..165; 180..183; 186..189; 204..210; 223..230; 239..247; 257..266; 272..274; 285..289; 302..309; 320..326; 332..338; 368..370; 386..389; 394..397; 401..406; 408..417; 423..431; 436..440; 451..456; 467..471; 476..480; 482..489; 511..514; 517..520; 523..526; 533..535; 541..545; 551..556; 562..567; 573..579; 582..587; 592..602; 609..619; 621..631
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
9..21; Low complexity
Motif
267..269; Cell attachment site
Domain (FT)
53..490; Sema; 544..629; Ig-like C2-type
Region
1..21; Disordered; 267..269; Interaction with integrins
Protein Families
Semaphorin family
Sequence Similarities
Belongs to the semaphorin family.
Clinical Relevance
Disease Involvement (2)
Disease variantIntrahepatic cholestasis
Related Diseases
Supporting Publications10
| PMID | Title | Related sentences |
|---|---|---|
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No related sentences available |
| 33309826 | Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts. | No related sentences available |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No related sentences available |
| 34576246 | Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators. | No related sentences available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No related sentences available |
| 37204515 | Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 39001700 | Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles. | No related sentences available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No related sentences available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No related sentences available |