Protein detail

SEM7A

Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)

Entry name SEM7A	UniProt ID O75326	EVMP confidence score 0.38
Supporting publications (n) 10	Transmembrane count	Protein classification Blood group antigen proteinsCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)

Protein Class (6)

Blood group antigen proteinsCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins

Protein Function (4)

Disease related genes
Blood group antigen proteins
Human disease related genes:Digestive system diseases:Liver diseases
CD markers

Ensembl

ENSG00000138623

Entrez Gene Symbol

SEMA7A

Gene Synonym (3)

CD108H-Sema-LSEMAL

Gene Description

Semaphorin 7A (John Milton Hagen blood group)

Chromosome

Position

74409289-74433958

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificEsophageal apical cells

Function & Pathway8

Protein Function (4)

Disease related genes
Blood group antigen proteins
Human disease related genes:Digestive system diseases:Liver diseases
CD markers

Cellular Component (6)

Molecular Function (5)

Biological Process (3)

KEGG

hsa04360 Axon guidance

Reactome (3)

Canonical Pathways (2)

M137 Pid vegf vegfr pathway
M274 Pid lymph angiogenesis pathway

Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence53

Ligand-Receptor Signaling (49)

49 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	Yes	Yes
semaphorin	cell_surface_ligand	HGNC	Yes	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	Yes
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	Yes
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	Yes
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	Yes
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	Yes

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SEM7A	O75326	PLXC1	O60486	Yes	Yes	No	iTALKICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:10520995 InnateDB:20727575 LRdb:10520995 CellTalkDB:10520995 HINT:20727575Baccin2019:1052099510520990HPMR:10520995 CellChatDB:27533782 Cellinker:26633812 Cellinker:27533782 IntAct:20727575 Lit-BM-17:20727575 SIGNOR:10520995 HPRD:10520995 ICELLNET:10520995 ICELLNET:17671519 connectomeDB2020:10520995
SEM7A	O75326		COMPLEX:P05556_P56199	Yes	Yes	No	CellChatDBCellPhoneDBICELLNETSIGNORCellPhoneDB_CellinkerCellinker	Cellinker:22325954 Cellinker:30568033 SIGNOR:17377534 CellChatDB:22325954 Cellinker:12879062 ICELLNET:17671519

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PlexinC1-SEMA7A complex	PLXNC1 SEMA7A	O60486 O75326	2:2	CompleatCORUMPDB	CORUM:5660PDB:3nvqCompleat:HC954	10520995

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38315424

Sequence, Structure & Domains15

Sequences

Length

666

Mass

74,824

Sequence

MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLTLGLLVH

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75326-1; Sequence=Displayed; Name=2; IsoId=O75326-2; Sequence=VSP_045349

Alternative Sequence

111..124; Missing (in isoform 2)

3D Structural Models

Turn

62..64; 146..148; 275..279; 294..296; 472..475; 537..540

Helix

235..237; 316..318; 339..348; 375..383; 499..505

Beta Strand

65..68; 77..79; 85..90; 92..99; 110..112; 129..136; 139..144; 151..158; 160..165; 180..183; 186..189; 204..210; 223..230; 239..247; 257..266; 272..274; 285..289; 302..309; 320..326; 332..338; 368..370; 386..389; 394..397; 401..406; 408..417; 423..431; 436..440; 451..456; 467..471; 476..480; 482..489; 511..514; 517..520; 523..526; 533..535; 541..545; 551..556; 562..567; 573..579; 582..587; 592..602; 609..619; 621..631

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

9..21; Low complexity

Motif

267..269; Cell attachment site

Domain (FT)

53..490; Sema; 544..629; Ig-like C2-type

Region

1..21; Disordered; 267..269; Interaction with integrins

Protein Families

Semaphorin family

Sequence Similarities

Belongs to the semaphorin family.

Clinical Relevance2

Disease Involvement (2)

Disease variantIntrahepatic cholestasis

Antibody (2)

HPA008210 HPA042273

Supporting Publications10

PMID	Title	Abstract
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
33309826	Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
39001700	Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.	No abstract available
40840701	Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available