Protein detail

DEAF1

Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5)

Entry name DEAF1	UniProt ID O75398	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification CD markersPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5)

Protein Class (2)

CD markersPredicted membrane proteins

Protein Function

CD markers

Ensembl

ENSG00000197471

Entrez Gene Symbol

SPN

Gene Synonym (4)

CD43GPL115LEU-22LSN

Gene Description

Sialophorin

Chromosome

Position

29662979-29670876

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificbone marrowBrain Regional Specificbasal gangliaCell SpecificBrain inhibitory neuronsSingle-Nuclei Brain Specificmedium spiny neuron

Function & Pathway7

Protein Function

CD markers

Cellular Component (10)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04514 Cell adhesion molecule (CAM) interaction

Reactome (3)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence54

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SPN	PRKCA	P17252	S	351	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper	phosphoELM:2530225 KEA:2530225
SPN	PRKCA	P17252	T	341	phosphorylation	PhosphoNetworks

Ligand-Receptor Signaling (43)

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
adhesion	adhesion	MCAM	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No

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Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
KPNB1-SMN-SPN complex	KPNB1 SMN1 SPN	P16150 Q14974 Q16637	0:0:0	CORUM	CORUM:7543	12095920
	CHEK1 CLSPN	O14757 Q9HAW4	2:2	PDB	PDB:7ako
	CDC45 CLSPN GINS1 GINS2 GINS3 GINS4 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 POLA1 POLA2 PRIM1 PRIM2 TIMELESS TIPIN WDHD1	O75419 O75717 P09884 P25205 P33991 P33992 P33993 P49642 P49643 P49736 Q14181 Q14566 Q14691 Q9BRT9 Q9BRX5 Q9BVW5 Q9HAW4 Q9UNS1 Q9Y248	1:3:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:8b9d
	CDC45 CLSPN CUL2 ELOB ELOC GINS1 GINS2 GINS3 GINS4 LRR1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 POLE POLE2 RBX1 TIMELESS TIPIN WDHD1	O75419 O75717 P25205 P33991 P33992 P33993 P49736 P56282 P62877 Q07864 Q13617 Q14566 Q14691 Q15369 Q15370 Q96L50 Q9BRT9 Q9BRX5 Q9BVW5 Q9HAW4 Q9UNS1 Q9Y248	1:3:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:7plo
	CDC45 CLSPN GINS1 GINS2 GINS3 GINS4 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 POLE POLE2 TIMELESS TIPIN WDHD1	O75419 O75717 P25205 P33991 P33992 P33993 P49736 P56282 Q07864 Q14566 Q14691 Q9BRT9 Q9BRX5 Q9BVW5 Q9HAW4 Q9UNS1 Q9Y248	1:3:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:7pfo
	CLSPN GINS1 GINS2 GINS3 TIMELESS TIPIN	Q14691 Q9BRX5 Q9BVW5 Q9HAW4 Q9UNS1 Q9Y248	0:0:0:0:0:0	hu.MAP
	CLSPN GINS1 GINS2 GINS3	Q14691 Q9BRX5 Q9HAW4 Q9Y248	0:0:0:0	hu.MAP
	SPNS2	Q8IVW8	2	PDB	PDB:8rl7

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Flow cytometry	1	30408591

Sequence, Structure & Domains14

Sequences

Length

565

Mass

59,327

Sequence

MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEASVQPPCRASHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPPTPTKAAPPALVNGLELSEPRSWLYLEEMVNSLLNTAQQLKTLFEQAKHASTYREAATNQAKIHADAERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHICGQSAAVTVQADEVHVAESVMEKVTV

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Hu-DF1; IsoId=O75398-1; Sequence=Displayed; Name=2; Synonyms=NUDR8; IsoId=O75398-3; Sequence=VSP_005967; Name=3; Synonyms=Suppressin; IsoId=O75398-4; Sequence=VSP_005966; Name=4; Synonyms=Hu-DF1-VAR; IsoId=O75398-5; Sequence=VSP_038701, VSP_038702

Alternative Sequence

1..68; Missing (in isoform 3); 15..29; EAAAVAAAAAVAAAA -> D (in isoform 2); 223..333; GRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTF -> WDLKPSRCLLHLCCLLRRHDLI (in isoform 4); 501; E -> EVIHPPRLPKVLGLQ (in isoform 4)

3D Structural Models

Turn

516..518; 533..535; 539..541

Helix

456..463; 526..532; 536..538

Beta Strand

505..510; 512..514; 520..525

3D Structure

NMR spectroscopy (2); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

169..181; Pro residues

Motif

301..316; Nuclear localization signal

Zinc Finger

504..540; MYND-type

Domain (FT)

193..273; SAND

Region

34..62; Disordered; 162..190; Disordered; 403..478; Interaction with LMO4

Clinical Relevance4

Antibody (2)

CAB002666 HPA055244

Interaction Protein

ENSG00000100097

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available