Protein detail
GPC4
Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]
Protein symbol GPC4 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Ensembl
Entrez Gene Symbol
Gene Synonym
K-glypican
Gene Description
Glypican 4
Chromosome
X
Position
133300103-133415489
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Cellular Component
Molecular Function
Reactome
- R-hsa-9694614 attachment and entry
- R-hsa-3560783 defective b4galt7 causes eds progeroid type
- R-hsa-3656237 defective ext2 causes exostoses 2
- R-hsa-9918485 dengue virus attachment and entry
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-9772572 early sars cov 2 infection events
- R-hsa-1630316 glycosaminoglycan metabolism
- R-hsa-1971475 glycosaminoglycan protein linkage region biosynthesis
- R-hsa-1638091 heparan sulfate heparin hs gag metabolism
- R-hsa-2022928 hs gag biosynthesis
- R-hsa-2024096 hs gag degradation
- R-hsa-5663205 infectious disease
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
- R-hsa-6806667 metabolism of fat soluble vitamins
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9820960 respiratory syncytial virus rsv attachment and entry
- R-hsa-9833110 rsv host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-9709957 sensory perception
- R-hsa-9824446 viral infection pathways
- R-hsa-2187338 visual phototransduction
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | Yes |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | Yes |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | Yes |
| receptor | receptor | LRdb | No | Yes | Yes | Yes | Yes |
| receptor | receptor | Baccin2019 | No | Yes | Yes | Yes | Yes |
| cytokine | receptor | Baccin2019 | No | Yes | Yes | Yes | Yes |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | Yes |
| ecm | ecm | CellCellInteractions | Yes | No | Yes | Yes | Yes |
| ecm | ecm | OmniPath | Yes | No | Yes | Yes | Yes |
| extracellular | extracellular | DGIdb | No | No | Yes | Yes | Yes |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GPC4 | O75487 | WNT3A | P56704 | Yes | Yes | No | SIGNOR | SIGNOR:22302992 |
| GPC4 | O75487 | WNT5A | P41221 | Yes | Yes | No | SIGNOR | SIGNOR:22302992 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27894104 |
Sequence, Structure & Domains
Sequences
Length
556
Mass
62,412
Sequence
MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75487-1; Sequence=Displayed; Name=2; IsoId=O75487-2; Sequence=VSP_056570
Alternative Sequence
1..70; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
Glypican family
Sequence Similarities
Belongs to the glypican family.
Clinical Relevance
Disease Involvement
DeafnessDisease variantIntellectual disability
Interaction Protein
ENSG00000140319ENSG00000164076ENSG00000183098
Interaction Count
3
Interaction Dataset
biogrid_opencell_bioplexbiogrid_bioplexintact_biogrid