Protein detail
GPC4
Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]
Entry name GPC4 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]
Protein Class (4)
Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function (2)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Ensembl
Entrez Gene Symbol
Gene Synonym
K-glypican
Gene Description
Glypican 4
Chromosome
X
Position
133300103-133415489
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway6
Protein Function (2)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Cellular Component (10)
Molecular Function (2)
Reactome (27)
- R-hsa-9694614 attachment and entry
- R-hsa-3560783 defective b4galt7 causes eds progeroid type
- R-hsa-3656237 defective ext2 causes exostoses 2
- R-hsa-9918485 dengue virus attachment and entry
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-9772572 early sars cov 2 infection events
Page 1 of 3
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence58
Ligand-Receptor Signaling (54)
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | EMBRACE | No | Yes | Yes | Yes | Yes |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | Yes |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | Yes |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | Yes |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GPC4 | O75487 | WNT3A | P56704 | Yes | Yes | No | SIGNOR | SIGNOR:22302992 |
| GPC4 | O75487 | WNT5A | P41221 | Yes | Yes | No | SIGNOR | SIGNOR:22302992 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27894104 |
Sequence, Structure & Domains7
Sequences
Length
556
Mass
62,412
Sequence
MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75487-1; Sequence=Displayed; Name=2; IsoId=O75487-2; Sequence=VSP_056570
Alternative Sequence
1..70; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
Glypican family
Sequence Similarities
Belongs to the glypican family.
Clinical Relevance6
Disease Involvement (3)
DeafnessDisease variantIntellectual disability
Interaction Protein (3)
ENSG00000140319ENSG00000164076ENSG00000183098
Interaction Count
3
Interaction Dataset (3)
biogrid_opencell_bioplexbiogrid_bioplexintact_biogrid
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40033163 | Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer. | No abstract available |