Protein detail
TNR21
Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Entry name TNR21 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Protein Class (3)
CD markersPlasma proteinsPredicted membrane proteins
Protein Function
CD markers
Transmembrane
350..370; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CD358DR6
Gene Description
TNF receptor superfamily member 21
Chromosome
6
Position
47231532-47309905
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificColonocytesSingle-Nuclei Brain Specificendothelial cell
Function & Pathway7
Protein Function
CD markers
Cellular Component
Molecular Function
Biological Process (3)
Reactome (8)
- R-hsa-3371568 attenuation phase
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-3371556 cellular response to heat stress
- R-hsa-3371511 hsf1 activation
- R-hsa-3371571 hsf1 dependent transactivation
- R-hsa-556833 metabolism of lipids
- R-hsa-3371453 regulation of hsf1 mediated heat shock response
- R-hsa-400206 regulation of lipid metabolism by pparalpha
Mediation Categories (3)
Adhesion and uptake mediationImmune mediationMetabolism mediation
Relations & Evidence62
Ligand-Receptor Signaling (58)
58 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| tnf_receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| cytokine | receptor | Baccin2019 | No | Yes | No | Yes | No |
| tnf_ngf | receptor | HPMR | No | Yes | No | Yes | No |
| tnr8_tnf_ngf | receptor | HPMR | No | Yes | No | Yes | No |
| tnfngf | receptor | Surfaceome | No | Yes | No | Yes | No |
| cytokine | receptor | ICELLNET | No | Yes | No | Yes | No |
| cytokine_tnf | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TNR21 | O75509 | TRADD | Q15628 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:14585074HPRD:9714541 |
| TNFA | P01375 | TNR21 | O75509 | Yes | Yes | No | HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbEMBRACEHPMR_talklr | HPMR:9714541LRdb:9714541Baccin2019:9714541CellTalkDB:9714541Cellinker:9714541SIGNOR:9714541connectomeDB2020:9714541 |
Protein Complex Composition (1)
Sequence, Structure & Domains11
Sequences
Length
655
Mass
71,845
Sequence
MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
3D Structural Models
Turn
59..61
Helix
193..195; 579..591; 598..606; 609..616; 621..635; 637..650; 652..654
Beta Strand
53..57; 64..68; 74..78; 82..84; 87..90; 99..101; 118..121; 130..132; 137..140; 143..146; 154..158; 162..164; 167..170; 181..183; 198..201; 205..207; 210..212; 571..573
3D Structure
NMR spectroscopy (1); X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
243..261; Polar residues; 268..282; Polar residues
Repeat
50..88; TNFR-Cys 1; 90..131; TNFR-Cys 2; 133..167; TNFR-Cys 3; 170..211; TNFR-Cys 4
Domain (FT)
415..498; Death
Region
243..286; Disordered; 318..337; Disordered
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No abstract available |
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | No abstract available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |