Protein detail
ADAP1
Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25)
Protein symbol ADAP1 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CENTA1GCS1L
Gene Description
ArfGAP with dual PH domains 1
Chromosome
7
Position
897900-955407
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ADAP1 | PRKCA | P17252 | S | 87 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:12893243KEA:12893243ProtMapper:12893243 |
| ADAP1 | PRKCA | P17252 | T | 276 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:12893243KEA:12893243ProtMapper:12893243 |
| ADAP1 | PRKCE | Q02156 | T | 276 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:12893243KEA:12893243ProtMapper:12893243 |
| ADAP1 | PRKCE | Q02156 | S | 87 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:12893243KEA:12893243ProtMapper:12893243 |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCE | Q02156 | ADAP1 | O75689 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEAInnateDBSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:12893243InnateDB:12893243HPRD:12893243SIGNOR:12893243KEA:12893243PhosphoSite:12893243 |
| KPCA | P17252 | ADAP1 | O75689 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDKEAHPRD_KEAInnateDBSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:12893243InnateDB:12893243HPRD:12893243SIGNOR:12893243KEA:12893243 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
374
Mass
43,395
Sequence
MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75689-1; Sequence=Displayed; Name=2; IsoId=O75689-2; Sequence=VSP_054794; Name=3; IsoId=O75689-3; Sequence=VSP_054793
Alternative Sequence
1..72; Missing (in isoform 3); 1..27; MAKERRRAVLELLQRPGNARCADCGAP -> MFQFVFSRVYCINPARRKWKEFEKMLGCAEEGHASLGR (in isoform 2)
3D Structural Models
Turn
22..24; 34..37; 52..54; 60..62; 86..88; 117..119; 155..158
Helix
3..12; 16..18; 42..49; 67..75; 78..85; 102..113; 121..124; 125..128; 177..179; 186..189; 215..236; 242..245; 246..248; 302..304; 341..356; 363..369
Beta Strand
31..33; 38..40; 57..59; 129..139; 141..143; 146..154; 159..163; 165..167; 172..176; 180..184; 195..201; 204..211; 237..240; 254..261; 271..278; 281..287; 294..298; 307..311; 323..328; 333..340
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Zinc Finger
21..44; C4-type
Domain (FT)
7..126; Arf-GAP; 129..230; PH 1; 252..356; PH 2