Protein detail

ADAP1

Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25)

Entry name ADAP1	UniProt ID O75689	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000105963

Entrez Gene Symbol

ADAP1

Gene Synonym (2)

CENTA1GCS1L

Gene Description

ArfGAP with dual PH domains 1

Chromosome

Position

897900-955407

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (6)

Biological Process (3)

Reactome (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence13

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ADAP1	PRKCA	P17252	S	87	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:12893243 KEA:12893243 ProtMapper:12893243
ADAP1	PRKCA	P17252	T	276	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:12893243 KEA:12893243 ProtMapper:12893243
ADAP1	PRKCE	Q02156	T	276	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:12893243 KEA:12893243 ProtMapper:12893243
ADAP1	PRKCE	Q02156	S	87	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:12893243 KEA:12893243 ProtMapper:12893243

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCE	Q02156	ADAP1	O75689	Yes	No	No	PhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEAInnateDBSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:12893243 InnateDB:12893243 HPRD:12893243 SIGNOR:12893243 KEA:12893243 PhosphoSite:12893243
KPCA	P17252	ADAP1	O75689	Yes	No	No	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDKEAHPRD_KEAInnateDBSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:12893243 InnateDB:12893243 HPRD:12893243 SIGNOR:12893243 KEA:12893243

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	38731868 40784529

Sequence, Structure & Domains11

Sequences

Length

374

Mass

43,395

Sequence

MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75689-1; Sequence=Displayed; Name=2; IsoId=O75689-2; Sequence=VSP_054794; Name=3; IsoId=O75689-3; Sequence=VSP_054793

Alternative Sequence

1..72; Missing (in isoform 3); 1..27; MAKERRRAVLELLQRPGNARCADCGAP -> MFQFVFSRVYCINPARRKWKEFEKMLGCAEEGHASLGR (in isoform 2)

3D Structural Models

Turn

22..24; 34..37; 52..54; 60..62; 86..88; 117..119; 155..158

Helix

3..12; 16..18; 42..49; 67..75; 78..85; 102..113; 121..124; 125..128; 177..179; 186..189; 215..236; 242..245; 246..248; 302..304; 341..356; 363..369

Beta Strand

31..33; 38..40; 57..59; 129..139; 141..143; 146..154; 159..163; 165..167; 172..176; 180..184; 195..201; 204..211; 237..240; 254..261; 271..278; 281..287; 294..298; 307..311; 323..328; 333..340

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Zinc Finger

21..44; C4-type

Domain (FT)

7..126; Arf-GAP; 129..230; PH 1; 252..356; PH 2

Clinical Relevance1

Antibody (2)

HPA007033 HPA012049

Supporting Publications2

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available
40689422	Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.	No abstract available