Protein detail
BCAR3
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Entry name BCAR3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
AND-34MIG7NSP2SH2D3B
Gene Description
BCAR3 adaptor protein, NSP family member
Chromosome
1
Position
93561741-93847150
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue Specificheart muscleCell SpecificAstrocytesSingle-Nuclei Brain Specificpericyte
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence6
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Sequence, Structure & Domains13
Sequences
Length
825
Mass
92,566
Sequence
MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75815-1; Sequence=Displayed; Name=2; IsoId=O75815-2; Sequence=VSP_017814; Name=3; IsoId=O75815-3; Sequence=VSP_046716, VSP_046717
Alternative Sequence
1..324; Missing (in isoform 2); 1..91; Missing (in isoform 3); 92..117; ESPWQDRHGETFTFRDPHLLDPTVEY -> MPKECSAFHALSAALCCFYHRKSFIG (in isoform 3)
3D Structural Models
Turn
765..767
Helix
517..519; 534..546; 549..563; 571..577; 582..585; 589..591; 592..614; 620..639; 644..655; 657..660; 663..672; 674..682; 684..692; 696..698; 711..717; 724..726; 732..734; 737..752; 754..764; 772..777; 780..792; 797..815
Beta Strand
578..580
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
79..94; Polar residues; 95..106; Basic and acidic residues
Domain (CC)
The SH2 domain mediates interaction with tyrosine-phosphorylated proteins (PubMed:18722344). However, not involved in the binding to phosphorylated BCAR1 (PubMed:18722344). Required for cell cycle progression in response to INS/insulin (PubMed:24216110). Required for regulation of EFR-induced DNA synthesis (PubMed:18722344).; DOMAIN: The Ras-GEF domain appears to adopt a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is probably required for interaction with BCAR1..
Domain (FT)
154..253; SH2; 548..818; Ras-GEF
Region
40..106; Disordered; 744..748; Mediates the interaction with BCAR1/p130CAS
Clinical Relevance5
Drugs
Antibody
Interaction Protein (4)
ENSG00000050820ENSG00000111859ENSG00000140961ENSG00000169047
Interaction Count
4
Interaction Dataset (2)
biogrid_opencell_bioplexintact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |