Protein detail
FLOT1
Flotillin-1
Entry name FLOT1 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Flotillin-1
Protein Class
Plasma proteinsPredicted intracellular proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Description
Flotillin 1
Chromosome
6
Position
30727709-30742732
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0001931 uropod
- GO:0005765 lysosomal membrane
- GO:0005768 endosome
- GO:0005769 early endosome
- GO:0005815 microtubule organizing center
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0005911 cell-cell junction
- GO:0005912 adherens junction
- GO:0005925 focal adhesion
- GO:0008180 COP9 signalosome
- GO:0009897 external side of plasma membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016600 flotillin complex
- GO:0030027 lamellipodium
- GO:0030864 cortical actin cytoskeleton
- GO:0031410 cytoplasmic vesicle
- GO:0034451 centriolar satellite
- GO:0042383 sarcolemma
- GO:0042470 melanosome
- GO:0044291 cell-cell contact zone
- GO:0045121 membrane raft
- GO:0048786 presynaptic active zone
- GO:0070062 extracellular exosome
- GO:0098691 dopaminergic synapse
- GO:0098978 glutamatergic synapse
- GO:0098982 GABA-ergic synapse
Molecular Function
Biological Process
Reactome
- R-hsa-112316 neuronal system
- R-hsa-5357801 programmed cell death
- R-hsa-6794362 protein protein interactions at synapses
- R-hsa-5218859 regulated necrosis
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-5213460 ripk1 mediated regulated necrosis
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-8849932 synaptic adhesion like molecules
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FLOT1 | SRC | P12931 | Y | 56 | phosphorylation | Sparser_ProtMapperProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:26923594 |
| FLOT1 | SRC | P12931 | Y | 149 | phosphorylation | Sparser_ProtMapperProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:26923594 |
| FLOT1 | FYN | P06241 | Y | 160 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| FLOT1 | PRKCA | P17252 | S | 315 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| flotillin | intracellular_intercellular_related | HGNC | No | Yes | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
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Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | FLOT1 | O75955 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_norefSIGNORiPTMnetProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:24983503ProtMapper:26923594SIGNOR:24983503 |
| FYN | P06241 | FLOT1 | O75955 | Yes | No | No | iPTMnetPhosphoPointProtMapperHPRDREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:19258392ProtMapper:32297092HPRD:11598189 |
| KPCA | P17252 | FLOT1 | O75955 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:21399631PhosphoSite:31753918 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
427
Mass
47,355
Sequence
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75955-1; Sequence=Displayed; Name=2; IsoId=O75955-2; Sequence=VSP_056227
Alternative Sequence
71..118; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Protein Families
- Band 7/mec-2 family
- Flotillin subfamily
Sequence Similarities
Belongs to the band 7/mec-2 family. Flotillin subfamily.