Protein detail
CBPD
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
Entry name CBPD | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 16 | Transmembrane count 1 | Protein classification EnzymesPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
Protein Class (3)
EnzymesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (4)
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Transmembrane
1300..1320; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GP180
Gene Description
Carboxypeptidase D
Chromosome
17
Position
30378927-30469989
Supporting publications (n)
16
EVMP confidence score
0.72
Fluorescence & Localization
Tissue SpecificbrainCell SpecificCone photoreceptor cellsBlood Cell Specificbasophil
Function & Pathway
Protein Function (4)
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (4)
Molecular Function (3)
Biological Process
Reactome (8)
- R-hsa-432722 golgi associated vesicle biogenesis
- R-hsa-199991 membrane trafficking
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696273 rnd1 gtpase cycle
- R-hsa-9696264 rnd3 gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-199992 trans golgi network vesicle budding
- R-hsa-5653656 vesicle mediated transport
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence36
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes | ||||
| cell_surface | cell_surface | OmniPath | Yes | ||||
| receptor | receptor | scConnect | Yes | Yes | |||
| transmembrane | transmembrane_predicted | Phobius | Yes | ||||
| transmembrane_phobius | transmembrane_predicted | Almen2009 | Yes | ||||
| transmembrane_sosui | transmembrane_predicted | Almen2009 | Yes | ||||
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | Yes |
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Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CPD | O75976 | 2 | PDB | PDB:5aq0 | ||
| GPCPD1SLC35D3 | Q5M8T2Q9NPB8 | 0:0 | hu.MAP2 | |||
| SCCPDHUSP13 | Q8NBX0Q92995 | 0:0 | hu.MAP | |||
| CRIPTSCCPDHTMEM160USP13 | Q8NBX0Q92995Q9NX00Q9P021 | 0:0:0:0 | hu.MAP2 | |||
| CRIPTSCCPDHUSP13 | Q8NBX0Q92995Q9P021 | 0:0:0 | hu.MAP2 | |||
| GPCPD1 | Q9NPB8 | 6 | PDB | PDB:2z0b |
Sequence, Structure & Domains
Sequences
Length
1,380
Mass
152,931
Sequence
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75976-1; Sequence=Displayed; Name=2; IsoId=O75976-2; Sequence=VSP_045833, VSP_045834
Alternative Sequence
1..2; MA -> MR (in isoform 2); 3..249; Missing (in isoform 2)
3D Structural Models
Turn
391..393
Beta Strand
383..390; 401..404; 417..422; 425..433; 440..447; 449..451; 457..459
3D Structure
Electron microscopy (2); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
195..204; Gly residues; 887..897; Polar residues
Motif
162..164; Cell attachment site
Domain (CC)
There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
Domain (FT)
57..380; Peptidase M14 1; 502..792; Peptidase M14 2; 932..1211; Peptidase M14 3
Region
190..232; Disordered; 874..899; Disordered; 1359..1380; Disordered
Protein Families
Peptidase M14 family
Sequence Similarities
Belongs to the peptidase M14 family.
Clinical Relevance
Drugs (11)
Antibody
Interaction Protein
ENSG00000127022
Interaction Count
1
Interaction Dataset
biogrid_opencell
Supporting Publications16
| PMID | Title | Related sentences |
|---|---|---|
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |
| 38168906 | Defining the relationship between cellular and extracellular vesicle (EV) content in breast cancer via an integrative multi-omic analysis. | No related sentences available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |
| 39409015 | SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy. | No related sentences available |
| 40089067 | Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells. | No related sentences available |
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