Protein detail
SASH3
SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog)
Protein symbol SASH3 | UniProt ID | EVMP score 0.50 |
Frequency 8 | Transmembrane count | Protein classification Disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog)
Protein Class
Disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
753P9CXorf9HACS2SH3D6CSLY
Gene Description
SAM and SH3 domain containing 3
Chromosome
X
Position
129779949-129795201
Frequency
8
EVMP Score
0.50
Fluorescence & Localization
Cell Specificmonocytes
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Biological Process
Mediation Categories
Adhesion and uptake mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SASH3 | PRKCB | P05771 | S | 27 | phosphorylation | KEA | KEA:17570479 |
| SASH3 | RPS6KA3 | P51812 | S | 27 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
380
Mass
41,595
Sequence
MLRRKPSNASEKEPTQKKKLSLQRSSSFKDFAKSKPSSPVVSEKEFNLDDNIPEDDSGVPTPEDAGKSGKKLGKKWRAVISRTMNRKMGKMMVKALSEEMADTLEEGSASPTSPDYSLDSPGPEKMALAFSEQEEHELPVLSRQASTGSELCSPSPGSGSFGEEPPAPQYTGPFCGRARVHTDFTPSPYDHDSLKLQKGDVIQIIEKPPVGTWLGLLNGKVGSFKFIYVDVLPEEAVGHARPSRRQSKGKRPKPKTLHELLERIGLEEHTSTLLLNGYQTLEDFKELRETHLNELNIMDPQHRAKLLTAAELLLDYDTGSEEAEEGAESSQEPVAHTVSEPKVDIPRDSGCFEGSESGRDDAELAGTEEQLQGLSLAGAP
3D Structural Models
Domain & Motif Annotations
Compositional Bias
22..41; Low complexity; 143..152; Polar residues; 153..164; Low complexity; 241..255; Basic residues; 318..327; Acidic residues
Domain (FT)
173..234; SH3; 252..316; SAM
Region
1..76; Disordered; 98..174; Disordered; 237..256; Disordered; 318..380; Disordered
Clinical Relevance
Disease Involvement
Disease variant
Antibody