Protein detail
CCN5
CCN family member 5 (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58) (WNT1-inducible-signaling pathway protein 2) (WISP-2)
Entry name CCN5 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Plasma proteinsPredicted secreted proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
CCN family member 5 (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58) (WNT1-inducible-signaling pathway protein 2) (WISP-2)
Protein Class (2)
Plasma proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CT58CTGF-LWISP-2WISP2
Gene Description
Cellular communication network factor 5
Chromosome
20
Position
44714844-44728509
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted secreted proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Canonical Pathways
M34 Pid tcr pathway
Mediation Categories
Other mediation
Relations & Evidence17
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | OmniPath | Yes | ||||
| glycoprotein | ecm | Matrisome | Yes | Yes | |||
| ccn_family | ligand | Matrisome | Yes | Yes | |||
| ccn | ligand | HGNC | Yes | Yes | |||
| ligand | ligand | HGNC | Yes | Yes | |||
| ligand | ligand | OmniPath | Yes | Yes |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western BlottingMass SpectrometryFlow Cytometry | 1 | 38207106 |
Sequence, Structure & Domains
Sequences
Length
250
Mass
26,825
Sequence
MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O76076-1; Sequence=Displayed; Name=2; IsoId=O76076-2; Sequence=VSP_056298, VSP_056299
Alternative Sequence
93..218; LAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSN -> CKQDPSFLALSLPCPLVSPAQNGARPGDPARPPVGWAWPPGCPTRTASADWRPSAACACPGPAHPPGVAVHKTVPSRAGLGMGTRCPPSPAGGPVPGPWADGRWSVPRPLAAGNTLAWVHHAEHQY (in isoform 2); 219..250; Missing (in isoform 2)
Domain & Motif Annotations
Domain (FT)
24..103; IGFBP N-terminal; 98..164; VWFC; 194..238; TSP type-1
Protein Families
CCN family
Sequence Similarities
Belongs to the CCN family.
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |