Protein detail
DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)
Entry name DDAH1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 6 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)
Protein Class (4)
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
DDAH
Gene Description
Dimethylarginine dimethylaminohydrolase 1
Chromosome
1
Position
85318481-85578363
Supporting publications (n)
6
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificblood vesselCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificneutrophil
Function & Pathway6
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
Reactome (2)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence11
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CBR3DDAH1GORASP2MTERF1PNPOUBE2G1 | O75828O94760P62253Q99551Q9H8Y8Q9NVS9 | 0:0:0:0:0:0 | hu.MAP2 | |||
| DDAH1 | O94760 | 2 | PDB | PDB:7uszPDB:3p8pPDB:7ulxPDB:3i2ePDB:3i4aPDB:7uluPDB:6szqPDB:7ulvPDB:3p8ePDB:7ut0PDB:2jajPDB:2jai | ||
| DDAH1DDAH2 | O94760O95865 | 0:0 | hu.MAPhu.MAP2 | |||
| DDAH1DDAH2TSC22D1 | O94760O95865Q15714 | 0:0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryR Sequencing | 1 | 31382537 |
Sequence, Structure & Domains11
Sequences
Length
285
Mass
31,122
Sequence
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O94760-1; Sequence=Displayed; Name=2; IsoId=O94760-2; Sequence=VSP_043813
Alternative Sequence
1..103; Missing (in isoform 2)
3D Structural Models
Turn
55..58; 72..75; 158..160; 228..230; 239..241
Helix
2..4; 25..28; 40..54; 77..80; 96..101; 102..111; 128..130; 148..157; 174..176; 192..204; 217..220; 243..249; 265..268; 273..275
Beta Strand
14..19; 61..65; 81..84; 87..90; 115..118; 131..133; 135..142; 161..167; 177..182; 185..189; 205..207; 210..216; 223..227; 231..236; 255..259; 277..279
3D Structure
X-ray crystallography (14)
Domain & Motif Annotations
Protein Families
DDAH family
Sequence Similarities
Belongs to the DDAH family.
Clinical Relevance2
Drugs
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 15326289 | Identification and proteomic profiling of exosomes in human urine. | No abstract available |
| 23161513 | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins. |
| 32249794 | Urinary Exosomes from Bladder Cancer Patients Show a Residual Cancer Phenotype despite Complete Pathological Downstaging. | No abstract available |
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |
| 33345401 | Paternal contributors in recurrent pregnancy loss: Cues from comparative proteome profiling of seminal extracellular vesicles. | No abstract available |
| 39940641 | Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients. | No abstract available |