Protein detail

STK10

Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)

Entry name STK10	UniProt ID O94804	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)

Protein Class

Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Kinases:STE Ser/Thr protein kinases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Ensembl

ENSG00000072786

Entrez Gene Symbol

STK10

Gene Synonym

LOKPRO2729

Gene Description

Serine/threonine kinase 10

Chromosome

Position

172042079-172188224

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificMelanocytesSingle-Nuclei Brain Specificendothelial cell

Function & Pathway

Protein Function

Kinases:STE Ser/Thr protein kinases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04914 Progesterone-mediated oocyte maturation

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
STK10	MAPK14	Q16539	S	438	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
STK10	O94804	EZRI	P15311	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperELMREACH_ProtMapperPhosphoSite_ProtMapper	ELM:33836044 ELM:19255442 ProtMapper:28430576 ELM:28430576 SIGNOR:28430576
STK10	O94804	MOES	P26038	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperELMdbPTMphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	dbPTM:19255442 phosphoELM:19255442 ELM:19255442 ProtMapper:19255442 SIGNOR:19255442

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	STK10	O94804	2	PDB	PDB:6i2yPDB:6hxfPDB:5ajqPDB:4equPDB:5owqPDB:4aotPDB:6eimPDB:4usePDB:4usd

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	6	31018934 32284825 38168906 28986585 27894104 38321535

Sequence, Structure & Domains

Sequences

Length

968

Mass

112,135

Sequence

MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS

3D Structural Models

Turn

56..58; 208..211; 236..239; 279..281; 292..296

Helix

32..34; 72..87; 118..125; 131..150; 160..162; 180..187; 196..198; 201..207; 213..216; 217..232; 242..251; 260..262; 265..274; 285..288; 301..314

Beta Strand

27..30; 36..41; 45..47; 50..55; 61..68; 96..102; 105..111; 163..165; 171..173

3D Structure

X-ray crystallography (14)

Domain & Motif Annotations

Compositional Bias

337..351; Polar residues; 361..393; Polar residues; 441..457; Polar residues; 835..865; Basic and acidic residues

Coiled Coil

573..947

Domain (FT)

36..294; Protein kinase

Region

175..224; Activation segment; 337..411; Disordered; 425..490; Disordered; 668..690; Disordered; 827..865; Disordered; 910..929; Disordered; 944..968; Disordered

Protein Families

Protein kinase superfamily
STE Ser/Thr protein kinase family
STE20 subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Clinical Relevance

Drugs

BOSUTINIB DDR1/2 INHIBITOR 5N HESPERADIN

Antibody

HPA015083 HPA015500 CAB020840