Protein detail

KPCD3

Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu)

Entry name KPCD3	UniProt ID O94806	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CAMK Ser/Thr protein kinases

Ensembl

ENSG00000115825

Entrez Gene Symbol

PRKD3

Gene Synonym (2)

EPK2PRKCN

Gene Description

Protein kinase D3

Chromosome

Position

37250502-37324833

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificNeutrophilsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway8

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CAMK Ser/Thr protein kinases

Cellular Component (3)

Molecular Function (7)

Biological Process (3)

KEGG (3)

Reactome (3)

Canonical Pathways (3)

M77 Pid wnt signaling pathway
M70 Pid ps1 pathway
M5493 Wnt signaling

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence19

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PRKD3	PRKCA	P17252	S	731	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:16198087

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (8)

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCD3	O94806	HDAC7	Q8WUI4	Yes	Yes	No	SIGNOR	SIGNOR:18692497
KPCD3	O94806	MFF	Q9GZY8	Yes	Yes	No	SIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:34010649
KPCD3	O94806	HDAC5	Q9UQL6	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_ProtMapper	SIGNOR:18692497
KPCD3	O94806	PAK4	O96013	Yes	Yes	No	SIGNOR	SIGNOR:23841590
KPCD3	O94806	GIT1	Q9Y2X7	Yes	No	No	Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:22893698 ProtMapper:33403031 ProtMapper:22893698 PhosphoSite:22893698
KPCD3	O94806	SSH1	Q8WYL5	Yes	No	Yes	RLIMS-P_ProtMapperSIGNORProtMapper	SIGNOR:21832093 ProtMapper:24840177
KPCD3	O94806	SRC8	Q14247	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:24753582 PhosphoSite:31727638 PhosphoSite:19038333 PhosphoSite:27179075 PhosphoSite:20363754
KPCA	P17252	KPCD3	O94806	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperKEAKinexus_KEAPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:16198087 KEA:16198087

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GCC2 IPO5 KPNA6 KPNB1 NUP107 NUP153 NUP214 NUP54 NUP98 NUTF2 PRKD3 RAN UBC XPOT	O00410 O43592 O60684 O94806 P0CG48 P35658 P49790 P52948 P57740 P61970 P62826 Q14974 Q7Z3B4 Q8IWJ2	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6476
	PRKD2 PRKD3	O94806 Q9BZL6	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	1	31852509

Sequence, Structure & Domains14

Sequences

Length

890

Mass

100,471

Sequence

MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O94806-1; Sequence=Displayed; Name=2; IsoId=O94806-2; Sequence=VSP_029405, VSP_029406

Alternative Sequence

595..611; HRKTGRDVAIKVIDKMR -> QLQPFAYCTHYFKNWKM (in isoform 2); 612..890; Missing (in isoform 2)

3D Structural Models

Turn

462..464; 508..514

Helix

517..532

Beta Strand

417..429; 434..443; 445..449; 477..479; 485..489; 494..497

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Zinc Finger

154..204; Phorbol-ester/DAG-type 1; 271..321; Phorbol-ester/DAG-type 2

Domain (FT)

416..532; PH; 576..832; Protein kinase

Region

332..371; Disordered

Protein Families (3)

Protein kinase superfamily
CAMK Ser/Thr protein kinase family
PKD subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

Clinical Relevance2

Supporting Publications1

PMID	Title	Abstract
28240915	Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy.	No abstract available