Protein detail

FCSD2

F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)

Entry name FCSD2	UniProt ID O94868	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000137478

Entrez Gene Symbol

FCHSD2

Gene Synonym (2)

KIAA0769SH3MD3

Gene Description

FCH and double SH3 domains 2

Chromosome

Position

72836745-73142318

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificintestineCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificmiscellaneous

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Canonical Pathways (2)

M77 Pid wnt signaling pathway
M5493 Wnt signaling

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence10

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
fbar_actin_dynamics_endocytosis	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ATG4D CNTLN FCHSD2 GOPC ZBTB5	O15062 O94868 Q86TL0 Q9HD26 Q9NXG0	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingELISA	2	38731868 40784529

Sequence, Structure & Domains14

Sequences

Length

740

Mass

84,276

Sequence

MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYDQPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPPPTQNHRRPAEKIEDVEITLV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O94868-1; Sequence=Displayed; Name=2; IsoId=O94868-2; Sequence=VSP_023167; Name=3; IsoId=O94868-3; Sequence=VSP_023167, VSP_023168, VSP_023169

Alternative Sequence

1..56; Missing (in isoform 2 and isoform 3); 569..571; VCF -> GKD (in isoform 3); 572..740; Missing (in isoform 3)

3D Structural Models

Turn

522..524

Helix

621..623

Beta Strand

470..476; 492..500; 503..511; 517..521; 571..576; 581..585; 593..598; 602..604; 606..612; 615..620; 624..626

3D Structure

NMR spectroscopy (2); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

307..323; Basic and acidic residues; 646..657; Pro residues

Coiled Coil

356..397

Domain (CC)

The F-BAR domain has an atypical, flat shape and binds preferentially to flat membranes. Upon heterologous expression, the isolated F-BAR domain is localized at the cell membrane, and causes the formation of cellular protrusions.; DOMAIN: Recruited to clathrin-coated pits via SH3 domain 2..; DOMAIN: The two SH3 domains cooperate to maintain the protein in an autoinhibited conformation that prevents promiscuous membrane binding.

Domain (FT)

8..282; F-BAR; 469..530; SH3 1; 567..629; SH3 2

Region

303..323; Disordered; 567..629; Required and sufficient for location at clathrin-coated pits; 633..740; Disordered

Clinical Relevance4

Antibody (2)

HPA038545 HPA038546

Interaction Protein (2)

ENSG00000151276ENSG00000165280

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available