Protein detail
TM63A
Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A) (hTMEM63A)
Entry name TM63A | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 11 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A) (hTMEM63A)
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
Transmembrane
52..74; Helical; Name=TM0; 135..167; Helical; Name=TM1; 192..217; Helical; Name=TM2; 417..444; Helical; Name=TM3; 463..490; Helical; Name=TM4; 496..532; Helical; Name=TM5; 555..586; Helical; Name=TM6; 607..624; Helical; Name=TM7; 629..651; Helical; Name=TM8; 662..689; Helical; Name=TM9; 695..709; Helical; Name=TM10
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization6
Tissue Specificheart muscleCell SpecificAdipocytesSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificmyeloid DCSecretome LocationSecreted to extracellular matrixSecretome FunctionNo annotated function
Function & Pathway7
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
Cellular Component (8)
Molecular Function (5)
Biological Process (3)
Canonical Pathways (3)
- M77 Pid wnt signaling pathway
- M23 Pid wnt noncanonical pathway
- M5493 Wnt signaling
Mediation Categories (3)
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence19
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 31852509 |
Sequence, Structure & Domains10
Sequences
Length
807
Mass
92,126
Sequence
MMDSPFLELWQSKAVSIREQLGLGDRPNDSYCYNSAKNSTVLQGVTFGGIPTVLLIDVSCFLFLILVFSIIRRRFWDYGRIALVSEADSESRFQRLSSTSSSGQQDFENELGCCPWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNDLLWLHTIFAVIYLFLTVGFMRHHTQSIKYKEENLVRRTLFITGLPRDARKETVESHFRDAYPTCEVVDVQLCYNVAKLIYLCKEKKKTEKSLTYYTNLQVKTGQRTLINPKPCGQFCCCEVLGCEWEDAISYYTRMKDRLLERITEEERHVQDQPLGMAFVTFQEKSMATYILKDFNACKCQSLQCKGEPQPSSHSRELYTSKWTVTFAADPEDICWKNLSIQGLRWWLQWLGINFTLFLGLFFLTTPSIILSTMDKFNVTKPIHALNNPIISQFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMIMAKTAADRRNVKQNQAFQYEFGAMYAWMLCVFTVIVAYSITCPIIAPFGLIYILLKHMVDRHNLYFVYLPAKLEKGIHFAAVNQALAAPILCLFWLYFFSFLRLGMKAPATLFTFLVLLLTILVCLAHTCFGCFKHLSPLNYKTEEPASDKGSEAEAHMPPPFTPYVPRILNGLASERTALSPQQQQQQTYGAIHNISGTIPGQCLAQSATGSVAAAPQEA
3D Structural Models
Turn
65..71; 402..405
Helix
13..19; 50..64; 137..166; 192..215; 248..251; 269..286; 321..349; 364..371; 386..388; 415..445; 455..457; 461..463; 467..488; 495..533; 554..573; 575..586; 591..598; 609..625; 629..631; 633..649; 661..688; 695..716
Beta Strand
72..75; 78..84; 173..176; 180..183; 187..189; 290..292; 446..450; 550..553; 652..655; 692..694
3D Structure
Electron microscopy (5)
Domain & Motif Annotations
Region
219..414; Intracellular linker IL2; confers mechanosensitivity; 555..586; Gating helix
Protein Families
CSC1 (TC 1.A.17) family
Sequence Similarities
Belongs to the CSC1 (TC 1.A.17) family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37338870 | Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2-dependent fashion. | No abstract available |