Protein detail

ARHGF

Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)

Entry name ARHGF	UniProt ID O94989	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000198844

Entrez Gene Symbol

ARHGEF15

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecifickidneyCell SpecificProximal tubule cellsSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (3)

Biological Process (3)

Reactome (11)

Page 1 of 2

Canonical Pathways (3)

M182 Pid il3 pathway
M234 Pid il2 stat5 pathway
M143 Pid il2 pi3k pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence9

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ARHGEF15	EPHB2	P29323	Y	353	phosphorylation	SIGNOR	SIGNOR:21029865

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EPHA4	P54764	ARHGF	O94989	Yes	Yes	No	PhosphoPointHPRDSignaLink3WangSPIKE_LC	SignaLink3:23331499 SignaLink3:12775584 HPRD:12775584 SPIKE_LC:16189514
ARHGF	O94989	RHOA	P61586	Yes	Yes	No	WangSIGNOR	SIGNOR:32203420
ARHGF	O94989	CDC42	P60953	Yes	Yes	No	SIGNOR	SIGNOR:32203420
EPHB2	P29323	ARHGF	O94989	Yes	No	Yes	Sparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapper	ProtMapper:21029865 ProtMapper:30682817 SIGNOR:21029865

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingELISA	2	38731868 40784529

Sequence, Structure & Domains6

Sequences

Length

841

Mass

91,940

Sequence

MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPPP

Domain & Motif Annotations

Compositional Bias

39..53; Polar residues; 65..110; Low complexity; 111..124; Pro residues

Domain (FT)

417..601; DH

Region

1..179; Disordered; 239..261; Disordered; 279..333; Disordered; 765..793; Disordered

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available