Protein detail
ZO3
Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)
Entry name ZO3 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)
Protein Class (2)
Predicted intracellular proteinsTransporters
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym
ZO-3
Gene Description
Tight junction protein 3
Chromosome
19
Position
3708362-3750813
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Cell SpecificBasal keratinocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DC
Function & Pathway
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence15
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | |||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | |||
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | |||
| tight_junction | tight_junction | OmniPath | Yes | Yes | |||
| maguk_tight_junction | intracellular_intercellular_related | OmniPath | Yes |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western BlottingMass SpectrometryFlow Cytometry | 1 | 38207106 |
Sequence, Structure & Domains
Sequences
Length
919
Mass
101,397
Sequence
MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=5; IsoId=O95049-1; Sequence=Displayed; Name=3; IsoId=O95049-3; Sequence=VSP_040238; Name=4; IsoId=O95049-4; Sequence=VSP_047022; Name=6; IsoId=O95049-5; Sequence=VSP_053844
Alternative Sequence
1..36; Missing (in isoform 6); 1; M -> MNLCGLMPIFPAPLDQVADM (in isoform 3); 1; M -> MAVRFQVADM (in isoform 4)
3D Structural Models
Turn
640..642
Helix
542..555; 596..602; 628..638; 661..669; 680..688; 703..713; 721..735; 736..738; 751..763
Beta Strand
478..482; 490..493; 501..506; 522..527; 533..539; 606..614; 621..625; 643..645; 673..676; 694..701; 740..745; 747..749; 766..771
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
117..131; Basic and acidic residues; 147..163; Basic residues; 332..360; Basic and acidic residues; 791..801; Low complexity; 812..828; Gly residues
Domain (FT)
11..93; PDZ 1; 195..272; PDZ 2; 380..446; PDZ 3; 475..549; SH3; 580..761; Guanylate kinase-like
Region
92..173; Disordered; 279..377; Disordered; 791..886; Disordered; 899..919; Disordered
Protein Families
MAGUK family
Sequence Similarities
Belongs to the MAGUK family.
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 39996590 | Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids. | No related sentences available |