Protein detail
S1PR2
Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5)
Entry name S1PR2 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification Disease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5)
Protein Class (5)
Disease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted membrane proteins
Protein Function (5)
- G-protein coupled receptors:Lysolipids receptors
- Potential drug targets
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- Human disease related genes:Nervous system diseases:Ear disease
Transmembrane
35..59; Helical; Name=1; 67..95; Helical; Name=2; 110..128; Helical; Name=3; 148..173; Helical; Name=4; 190..210; Helical; Name=5; 234..255; Helical; Name=6; 272..292; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
AGR16DFNB68EDG5Gpcr13H218
Gene Description
Sphingosine-1-phosphate receptor 2
Chromosome
19
Position
10221433-10231331
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization4
Cell SpecificChoroid plexus epithelial cellsBlood Cell SpecificT-regBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (5)
- G-protein coupled receptors:Lysolipids receptors
- Potential drug targets
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (5)
Molecular Function (7)
Biological Process (3)
KEGG (2)
Reactome (5)
Mediation Categories (2)
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence57
Ligand-Receptor Signaling (45)
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network (8)
8 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| S1PR2 | O95136 | GNA12 | Q03113 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049SIGNOR:22863277 |
| S1PR2 | O95136 | GNA13 | Q14344 | Yes | Yes | No | HPRDWangSIGNOR | SIGNOR:31160049HPRD:10488065SIGNOR:22863277 |
| S1PR2 | O95136 | GNAI1 | P63096 | Yes | Yes | No | HPRDWangSIGNOR | SIGNOR:31160049HPRD:10488065SIGNOR:10488065 |
| S1PR2 | O95136 | GNAI3 | P08754 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| S1PR2 | O95136 | GNAO | P09471 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| S1PR2 | O95136 | GNAZ | P19086 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| S1PR2 | O95136 | GNAQ | P50148 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:31160049HPRD:10488065SIGNOR:10488065 |
| S1PR2 | O95136 | GNA14 | O95837 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer Precipitation | Mass spectrometry|Western blottingMass spectrometryWestern blotting|Mass spectrometryWestern blottingMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]R Sequencing | 5 | 3199233522708494275745372886758536612209 |
Sequence, Structure & Domains9
Sequences
Length
353
Mass
38,867
Sequence
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
3D Structural Models
Turn
95..97; 261..263
Helix
14..20; 34..60; 68..90; 91..93; 102..135; 147..168; 190..218; 229..236; 237..239; 240..258; 267..269; 270..287
Beta Strand
136..138; 181..183
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance5
Disease Involvement (3)
DeafnessDisease variantNon-syndromic deafness
Related Diseases
Biomarker
Phase 2
Drugs (8)
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | No abstract available |
| 38136601 | Identification of Central Nervous System Oncologic Disease Biomarkers in EVs from Cerebrospinal Fluid (CSF) of Pediatric Patients: A Pilot Neuro-Proteomic Study. | No abstract available |