Protein detail

SPN1

Snurportin-1 (RNA U transporter 1)

Protein symbol SPN1	UniProt ID O95149	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Snurportin-1 (RNA U transporter 1)

Protein Class

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000169371

Entrez Gene Symbol

SNUPN

Gene Synonym

RNUT1SNURPORTIN-1Snurportin1

Gene Description

Snurportin 1

Chromosome

Position

75598083-75626469

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificCytotrophoblastsBlood Cell SpecificeosinophilBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa03013 Nucleocytoplasmic transport

Reactome

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SNUPN	PRKAA2	P54646	S	75	phosphorylation	PhosphoNetworks
SNUPN	STK17A	Q9UEE5	S	350	phosphorylation	PhosphoNetworks

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SPN1	O95149		COMPLEX:O43172_O43290_O75643_O94906_O95777_P09012_P14678_P55769_P62304_P62306_P62308_P62310_P62312_P62314_P62316_P62318_P83876_Q15029_Q53GS9_Q6P2Q9_Q8WVK2_Q8WWY3_Q96DI7_Q9BTD8_Q9BUQ8_Q9UK45_Q9Y333_Q9Y4Y9_Q9Y4Z0	Yes	Yes	No	SIGNOR	SIGNOR:9670026
SPN1	O95149		COMPLEX:O43719_O75533_P08579_P09661_P14678_P62304_P62306_P62308_P62314_P62316_P62318_Q12874_Q13435_Q15393_Q15427_Q15428_Q15459_Q7L014_Q7RTV0_Q8TAD8_Q9BRD0_Q9BWJ5_Q9Y388_Q9Y3B4	Yes	Yes	No	SIGNOR	SIGNOR:9670026
SPN1	O95149		COMPLEX:P08621_P09012_P09234_P14678_P62304_P62306_P62308_P62314_P62316_P62318	Yes	Yes	No	SIGNOR	SIGNOR:9670026
MEX3B	Q6ZN04	SPN1	O95149	Yes	No	Yes	HINTLit-BM-17SIGNOR	Lit-BM-17:21900206 HINT:24326307 SIGNOR:24326307 Lit-BM-17:24326307

Protein Complex Composition

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Importin complexSnurportin variant	KPNB1 SNUPN	O95149 Q14974	2:2	ComplexPortalPDB	intact:EBI-13645703PDB:2qnaPDB:3lwwPDB:2P8QPDB:2p8qPDB:2q5d	26173234 14755292 9670026 20476751 18187419
Snurportin-CRM1-RanGTP complex	RAN SNUPN XPO1	O14980 O95149 P62826	1:1:1	CompleatCORUM	CORUM:1045Compleat:HC3404	10209022
	SNUPN XPO1	O14980 O95149	1:1	PDB	PDB:3gb8
	NUP214 RAN SNUPN XPO1	O14980 O95149 P35658 P62826	1:1:1:1	PDB	PDB:5dis
	DPP9 PDP1 SNUPN SPRED2	O95149 Q7Z698 Q86TI2 Q9P0J1	0:0:0:0	hu.MAP2
	MRPL37 PDP1 SNUPN SPRED2	O95149 Q7Z698 Q9BZE1 Q9P0J1	0:0:0:0	hu.MAP2
	PDP1 SNUPN SPRED2	O95149 Q7Z698 Q9P0J1	0:0:0	hu.MAP2
	PDP1 SNUPN	O95149 Q9P0J1	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	4	40189497 38113368 40730843 38207106

Sequence, Structure & Domains

Sequences

Length

360

Mass

41,143

Sequence

MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN

3D Structural Models

Turn

61..63; 212..214; 216..219

Helix

1..10; 28..30; 42..60; 115..118; 178..180; 201..211; 239..246; 279..281; 282..286; 294..296

Beta Strand

21..23; 97..100; 102..107; 119..135; 138..142; 144..146; 148..152; 155..159; 161..163; 165..167; 170..177; 182..191; 197..199; 225..231; 234..236; 254..263; 268..277; 291..293

3D Structure

X-ray crystallography (11)

Domain & Motif Annotations

Compositional Bias

7..22; Polar residues

Domain (FT)

11..73; IBB

Region

1..159; Necessary for interaction with XPO1; 1..65; Necessary for interaction with KPNB1 and m3G-cap U1 and U5 snRNP import receptor activity; 1..42; Disordered; 127..129; Interaction with m3G-cap structure; 208..328; Necessary for binding to the m3G-cap structure; 339..360; Disordered

Protein Families

Snurportin family

Sequence Similarities

Belongs to the snurportin family.

Clinical Relevance

Disease Involvement

Disease variantLimb-girdle muscular dystrophy

Antibody

CAB005004 HPA069478

Interaction Protein

ENSG00000082898ENSG00000139343ENSG00000182004

Interaction Count

Interaction Dataset

intact_biogridbiogrid_opencell_bioplex