Protein detail

SCEL

Sciellin

Entry name SCEL	UniProt ID O95171	EVMP confidence score 0.72
Supporting publications (n) 20	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Sciellin

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000136155

Entrez Gene Symbol

SCEL

Gene Synonym (2)

FLJ21667MGC22531

Gene Description

Sciellin

Chromosome

Position

77535674-77645263

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificCytotrophoblasts

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence10

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
secreted	secreted	Cellinker	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
ligand	ligand	Cellinker	Yes	No	Yes	No	No
ligand	ligand	OmniPath	Yes	No	Yes	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	BPIFB2 CA6 CST5 FRMD1 LEG1 LPO RHOBTB1 SCEL SPRR3 VASH1 ZNF491	O94844 O95171 P22079 P23280 P28325 Q6P5S2 Q7L8A9 Q8N4F0 Q8N878 Q8N8L2 Q9UBC9	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32002171

Sequence, Structure & Domains9

Sequences

Length

688

Mass

77,552

Sequence

MSNVTLRKMSPTGNEMKSTTQGTTRKQQDFHEVNKRRTFLQDNSWIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRISDRNDAAKTYKANTLDNQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSATTPVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSPNQLRQDNRQIHPPKPGVYTETNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMNKSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKGRQNLESVAKVNARMNKTSRRSEDLDNATEVNPKGHENTTGKKDLDGLIKVDPETNKNITRGQSLDNLIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQSLDSLIKVTPERNRTNQGNQDLENLIKVIPSANKSSEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLDNLIKVKPSALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYSKIMAKWIP

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95171-1; Sequence=Displayed; Name=2; IsoId=O95171-2; Sequence=VSP_035980; Name=3; IsoId=O95171-3; Sequence=VSP_045288, VSP_045289

Alternative Sequence

160..181; Missing (in isoform 3); 231..251; RSQDLDNIVKVATSLQRSDKG -> S (in isoform 2); 367..386; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

1..25; Polar residues; 140..154; Low complexity; 186..195; Pro residues; 358..373; Basic and acidic residues

Repeat

251..266; 1; 267..286; 2; 287..306; 3; 307..326; 4; 327..346; 5; 347..366; 6; 367..386; 7; 387..406; 8; 407..426; 9; 427..446; 10; 447..465; 11; 466..484; 12; 485..504; 13; 505..523; 14; 524..543; 15; 544..563; 16

Domain (FT)

619..685; LIM zinc-binding

Region

1..29; Disordered; 134..231; Disordered; 251..563; 16 X approximate tandem repeats; 340..373; Disordered

Clinical Relevance1

Antibody (2)

HPA039737 HPA040154

Supporting Publications20

PMID	Title	Abstract
17671216	Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2.	IL-2-induced Foxp3 expression by CD4(+)CD25(+) cells was not inhibited by tumor exosomes, and the suppressive function of CD4(+)CD25(+) T cells was enhanced by exosomes. Other exosome effects included selective impairment of IL-2-mediated CD25 up-regulation, affecting all but the CD3(+)CD8(-) T-cell subset. Our study examined whether tumor-derived exosomes could modify lymphocyte IL-2 responses. Proliferation of healthy donor peripheral blood lymphocytes in response to IL-2 was inhibited by tumor exosomes. The data show an exosome-mediated mechanism of skewing IL-2 responsiveness in favor of regulatory T cells and away from cytotoxic cells.
18490724	Human tumor-derived exosomes down-modulate NKG2D expression.	Exosomes produced by various cancer cell lines in vitro, or isolated from pleural effusions of mesothelioma patients triggered down-regulation of surface NKG2D expression by NK cells and CD8(+) T cells. In this study, we show that exosomes derived from cancer cells express ligands for NKG2D and express TGFbeta1, and we investigate the impact of such exosomes on CD8(+) T and NK cell NKG2D expression and on NKG2D-dependent functions. This decrease was rapid, sustained, and resulted from direct interactions between exosomes and NK cells or CD8(+) T cells.
37029374	PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer.	No abstract available
37072829	Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes.	No abstract available
37253066	Schistosome egg antigen stimulates the secretion of miR-33-carrying extracellular vesicles from macrophages to promote hepatic stellate cell activation and liver fibrosis in schistosomiasis.	Here, we demonstrated that SEA induced Mφ to produce abundant extracellular vesicles, which directly activated HSCs by activating their autocrine TGF-β1 signaling.
37303669	Mesenchymal stem cell-derived exosomes ameliorate TGF-β1-induced endometrial fibrosis by altering their miRNA profile.	No abstract available
37321426	GuiLu-ErXian Glue extract promotes mesenchymal stem cells (MSC)-Induced chondrogenesis via exosomes release and delays aging in the MSC senescence process.	we conclude that GLEXG promotes in vitro MSC-induced chondrogenesis possibly via exosomes release and delays aging in the MSC senescence process and that treatment with GLEXG (0.3 μg, i.a.)
37357686	Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis.	No abstract available
37369038	Extravillous trophoblast cell-derived exosomes induce vascular smooth muscle cell apoptosis via a mechanism associated with miR-143-3p.	These data clearly demonstrated that VSMC apoptosis is mediated by EVT-derived exosomes and their cargo of miR-143-3p as well as their cell surface presentation of FASL.
37542121	Small EV in plasma of triple negative breast cancer patients induce intrinsic apoptosis in activated T cells.	Here we show that tumor cell-derived exosomes (TEX) carrying surface PDL-1, PD-1, Fas, FasL, TRAIL, CTLA-4 and TGF-β1 induce apoptosis of CD8 © 2023.

Page 1 of 2Next