Protein detail
UNC5C
Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)
Protein symbol UNC5C | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)
Protein Function
- Disease related genes
- Predicted intracellular proteins
Transmembrane
381..401; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificBreast secretory cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| UNC5C | SRC | P12931 | Y | 568 | phosphorylation | Reactome_ProtMapperProtMapper | |
| UNC5C | SRC | P12931 | Y | 449 | phosphorylation | Reactome_ProtMapperProtMapper | |
| UNC5C | SRC | P12931 | Y | 667 | phosphorylation | Reactome_ProtMapperProtMapper | |
| UNC5C | SRC | P12931 | Y | 454 | phosphorylation | Reactome_ProtMapperProtMapper | |
| UNC5C | SRC | P12931 | Y | 649 | phosphorylation | Reactome_ProtMapperProtMapper |
Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ig_like | receptor | Almen2009 | No | Yes | No | Yes | No |
| netrin | receptor | Almen2009 | No | Yes | No | Yes | No |
| netrin | receptor | HPMR | No | Yes | No | Yes | No |
| subfamily2_netrin | receptor | HPMR | No | Yes | No | Yes | No |
| ig | receptor | Surfaceome | No | Yes | No | Yes | No |
| netrinr | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| UNC5C | O95185 | DCC | P43146 | Yes | No | Yes | SIGNOR | SIGNOR:25881791 |
| NET1 | O95631 | UNC5C | O95185 | Yes | Yes | No | iTALKICELLNETSIGNORHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | SIGNOR:10399920HPMR:12810718Baccin2019:10399920Baccin2019:12810718connectomeDB2020:10399920Cellinker:12810718LRdb:12810718CellTalkDB:12810718HPRD:12810718Cellinker:10399920LRdb:1ICELLNET:12810718connectomeDB2020:12810718CellChatDB:22685302 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
931
Mass
103,146
Sequence
MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95185-1; Sequence=Displayed; Name=2; IsoId=O95185-2; Sequence=VSP_011700, VSP_011701
Alternative Sequence
370; T -> SFIYPISTEQRTQNEYGFSS (in isoform 2); 579..931; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (FT)
62..159; Ig-like; 161..256; Ig-like C2-type; 260..314; TSP type-1 1; 316..368; TSP type-1 2; 530..673; ZU5; 850..929; Death
Region
402..931; Required for netrin-mediated axon repulsion of neuronal growth cones; 694..712; Interaction with DCC
Protein Families
Unc-5 family
Sequence Similarities
Belongs to the unc-5 family.