Protein detail

UNC5C

Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)

Entry name UNC5C	UniProt ID O95185	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Transmembrane

381..401; Helical

Transmembrane Count

Ensembl

ENSG00000182168

Entrez Gene Symbol

UNC5C

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Cell SpecificBreast secretory cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway7

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (8)

Molecular Function (5)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence62

Enzyme-Mediated Modification (5)

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
UNC5C	SRC	P12931	Y	568	phosphorylation	Reactome_ProtMapperProtMapper
UNC5C	SRC	P12931	Y	449	phosphorylation	Reactome_ProtMapperProtMapper
UNC5C	SRC	P12931	Y	667	phosphorylation	Reactome_ProtMapperProtMapper
UNC5C	SRC	P12931	Y	454	phosphorylation	Reactome_ProtMapperProtMapper
UNC5C	SRC	P12931	Y	649	phosphorylation	Reactome_ProtMapperProtMapper

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
receptor	receptor	EMBRACE	No	Yes	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
UNC5C	O95185	DCC	P43146	Yes	No	Yes	SIGNOR	SIGNOR:25881791
NET1	O95631	UNC5C	O95185	Yes	Yes	No	iTALKICELLNETSIGNORHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	SIGNOR:10399920 HPMR:12810718 Baccin2019:10399920 Baccin2019:12810718 connectomeDB2020:10399920 Cellinker:12810718 LRdb:12810718 CellTalkDB:12810718 HPRD:12810718 Cellinker:10399920LRdb:1ICELLNET:12810718 connectomeDB2020:12810718 CellChatDB:22685302

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	7	36406491 38441169 40829696 26775013 39104279 35085587 37922300

Sequence, Structure & Domains9

Sequences

Length

931

Mass

103,146

Sequence

MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95185-1; Sequence=Displayed; Name=2; IsoId=O95185-2; Sequence=VSP_011700, VSP_011701

Alternative Sequence

370; T -> SFIYPISTEQRTQNEYGFSS (in isoform 2); 579..931; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

62..159; Ig-like; 161..256; Ig-like C2-type; 260..314; TSP type-1 1; 316..368; TSP type-1 2; 530..673; ZU5; 850..929; Death

Region

402..931; Required for netrin-mediated axon repulsion of neuronal growth cones; 694..712; Interaction with DCC

Protein Families

Unc-5 family

Sequence Similarities

Belongs to the unc-5 family.

Supporting Publications1

PMID	Title	Abstract
40326690	Rapid Identification of Esophageal Squamous Cell Carcinoma Biomarkers by MALDI-TOF MS Fingerprinting of Extracellular Vesicles.	No abstract available