Protein detail
LYPD3
Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)
Entry name LYPD3 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)
Protein Class
Predicted membrane proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
C4.4A
Gene Description
LY6/PLAUR domain containing 3
Chromosome
19
Position
43460787-43465608
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization6
Tissue SpecificintestineCell SpecificCardiomyocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificintermediate monocyteBlood Lineage Specificdendritic cells
Function & Pathway4
Cellular Component (4)
Molecular Function
Reactome (2)
Mediation Categories (2)
Adhesion and uptake mediationMetabolism mediation
Relations & Evidence29
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| peripheral | peripheral | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | No | No | No | Yes | Yes |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | Yes |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | Yes |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | Yes |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| LYPD3 | O95274 | 2 | PDB | PDB:6iom | ||
| LYPD3PEX11BPHTF1REEP1 | O95274O96011Q9H902Q9UMS5 | 0:0:0:0 | hu.MAP | |||
| DPY19L1LYPD3PHTF1REEP1 | O95274Q2PZI1Q9H902Q9UMS5 | 0:0:0:0 | hu.MAP | |||
| LYPD3PHTF1REEP1SLC41A1 | O95274Q8IVJ1Q9H902Q9UMS5 | 0:0:0:0 | hu.MAP | |||
| LYPD3PHTF1PHTF2REEP1 | O95274Q8N3S3Q9H902Q9UMS5 | 0:0:0:0 | hu.MAP | |||
| LYPD3PHTF1REEP1USP24 | O95274Q9H902Q9UMS5Q9UPU5 | 0:0:0:0 | hu.MAP |
Sequence, Structure & Domains10
Sequences
Length
346
Mass
35,971
Sequence
MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL
3D Structural Models
Turn
46..48; 148..150
Helix
164..166; 221..223
Beta Strand
32..42; 50..53; 61..70; 73..82; 87..96; 99..110; 139..141; 143..145; 158..160; 171..181; 184..195; 201..206; 209..216
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
234..246; Pro residues; 247..269; Low complexity; 283..295; Basic and acidic residues
Domain (FT)
33..126; UPAR/Ly6 1; 140..222; UPAR/Ly6 2
Region
233..324; Disordered
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 35563647 | Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue. | No abstract available |