Protein detail
RASL1
RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein)
Protein symbol RASL1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein)
Protein Class
Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
RASAL
Gene Description
RAS protein activator like 1
Chromosome
12
Position
113098819-113136239
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificEpididymal basal cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component
Molecular Function
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32002171 |
Sequence, Structure & Domains
Sequences
Length
804
Mass
90,016
Sequence
MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDRAHEEFQQQERGKAALGPLGP
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O95294-1; Sequence=Displayed; Name=2; IsoId=O95294-2; Sequence=VSP_001627; Name=3; IsoId=O95294-3; Sequence=VSP_047005, VSP_047006; Name=4; IsoId=O95294-4; Sequence=VSP_047006
Alternative Sequence
458; Q -> QQ (in isoform 3); 552; E -> EE (in isoform 3 and isoform 4); 610..637; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Zinc Finger
674..710; Btk-type
Domain (FT)
1..105; C2 1; 116..231; C2 2; 317..545; Ras-GAP; 565..672; PH
Clinical Relevance
Antibody