Protein detail

RASL1

RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein)

Entry name RASL1	UniProt ID O95294	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein)

Protein Class (3)

Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins

Protein Function (2)

Predicted intracellular proteins
RAS pathway related proteins

Ensembl

ENSG00000111344

Entrez Gene Symbol

RASAL1

Gene Synonym

RASAL

Gene Description

RAS protein activator like 1

Chromosome

Position

113098819-113136239

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization7

Tissue Specificchoroid plexusCell SpecificEpididymal basal cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway6

Protein Function (2)

Predicted intracellular proteins
RAS pathway related proteins

Cellular Component (2)

Molecular Function (3)

KEGG

hsa04014 Ras signaling pathway

Reactome (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence6

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32002171

Sequence, Structure & Domains7

Sequences

Length

804

Mass

90,016

Sequence

MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDRAHEEFQQQERGKAALGPLGP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O95294-1; Sequence=Displayed; Name=2; IsoId=O95294-2; Sequence=VSP_001627; Name=3; IsoId=O95294-3; Sequence=VSP_047005, VSP_047006; Name=4; IsoId=O95294-4; Sequence=VSP_047006

Alternative Sequence

458; Q -> QQ (in isoform 3); 552; E -> EE (in isoform 3 and isoform 4); 610..637; Missing (in isoform 2)

Domain & Motif Annotations

Zinc Finger

674..710; Btk-type

Domain (FT)

1..105; C2 1; 116..231; C2 2; 317..545; Ras-GAP; 565..672; PH

Clinical Relevance1

Antibody

HPA041650

Supporting Publications1

PMID	Title	Abstract
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available