Protein detail
ABCBB
Bile salt export pump (EC 7.6.2.-) (ATP-binding cassette sub-family B member 11)
Entry name ABCBB | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Bile salt export pump (EC 7.6.2.-) (ATP-binding cassette sub-family B member 11)
Protein Class (7)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Transporters:Primary Active Transporters
- Disease related genes
Transmembrane
63..83; Helical; 148..168; Helical; 216..236; Helical; 241..261; Helical; 320..340; Helical; 354..374; Helical; 756..776; Helical; 795..815; Helical; 870..890; Helical; 891..911; Helical; 980..1000; Helical; 1012..1032; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (6)
ABC16BSEPPFIC-2PFIC2PGY4SPGP
Gene Description
ATP binding cassette subfamily B member 11
Chromosome
2
Position
168915498-169031324
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificbone marrowCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Transporters:Primary Active Transporters
- Disease related genes
Cellular Component (10)
Molecular Function (8)
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008559 ABC-type xenobiotic transporter activity
- GO:0015125 bile acid transmembrane transporter activity
- GO:0015126 canalicular bile acid transmembrane transporter activity
- GO:0015144 carbohydrate transmembrane transporter activity
- GO:0015432 ABC-type bile acid transporter activity
- GO:0016887 ATP hydrolysis activity
KEGG (4)
Reactome (8)
- R-hsa-5619084 abc transporter disorders
- R-hsa-194068 bile acid and bile salt metabolism
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-556833 metabolism of lipids
- R-hsa-8957322 metabolism of steroids
- R-hsa-159418 recycling of bile acids and salts
- R-hsa-192105 synthesis of bile acids and bile salts
- R-hsa-193368 synthesis of bile acids and bile salts via 7alpha hydroxycholesterol
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence23
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| active | transporter | Surfaceome | No | Yes | No | No | No |
| abcb | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32002171 |
Sequence, Structure & Domains13
Sequences
Length
1,321
Mass
146,407
Sequence
MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPIS
3D Structural Models
Turn
105..107; 126..129; 349..352; 547..549; 585..588; 605..607; 641..645; 648..652; 688..700; 1207..1209; 1245..1248
Helix
47..51; 56..99; 134..182; 187..190; 195..213; 216..236; 242..286; 288..294; 297..343; 344..348; 356..374; 377..397; 461..468; 486..488; 491..496; 512..517; 525..534; 538..542; 554..556; 561..573; 591..603; 617..620; 653..655; 701..703; 740..747; 749..751; 752..780; 782..784; 793..840; 844..847; 850..852; 854..872; 875..894; 898..907; 909..945; 947..953; 956..1009; 1014..1027; 1030..1036; 1038..1040; 1041..1055; 1119..1126; 1144..1146; 1149..1154; 1170..1175; 1185..1194; 1198..1202; 1214..1216; 1221..1234; 1251..1264; 1277..1279; 1300..1305; 1309..1316
Beta Strand
111..115; 119..121; 237..241; 407..410; 420..428; 430..432; 435..445; 449..454; 475..481; 498..501; 509..511; 544..546; 578..584; 609..613; 624..630; 633..636; 704..706; 711..714; 1078..1085; 1092..1094; 1095..1097; 1101..1103; 1108..1114; 1127..1130; 1133..1139; 1140..1142; 1156..1159; 1167..1169; 1179..1181; 1204..1206; 1238..1244; 1266..1273; 1284..1290; 1293..1298
3D Structure
Electron microscopy (8)
Domain & Motif Annotations
Compositional Bias
21..37; Basic and acidic residues
Domain (CC)
Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Domain (FT)
62..385; ABC transmembrane type-1 1; 420..656; ABC transporter 1; 755..1043; ABC transmembrane type-1 2; 1078..1316; ABC transporter 2
Region
16..37; Disordered; 651..672; Interaction with HAX1; 1311..1314; Mediates internalization from the plasma membrane
Protein Families (3)
- ABC transporter superfamily
- ABCB family
- Multidrug resistance exporter (TC 3.A.1.201) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Clinical Relevance3
Disease Involvement (2)
Disease variantIntrahepatic cholestasis
Drugs (12)
Antibody
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 40831280 | Syntenin Controls Extracellular Vesicle-Induced Tumour Migration by Regulating the Expression of Adhesion Proteins on Small Extracellular Vesicles. | No abstract available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No abstract available |