Protein detail

SVIL

Supervillin (Archvillin) (p205/p250)

Entry name SVIL	UniProt ID O95425	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Supervillin (Archvillin) (p205/p250)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Ensembl

ENSG00000197321

Entrez Gene Symbol

SVIL

Gene Description

Supervillin

Chromosome

Position

29457338-29736959

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecificlungCell SpecificcDCSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificeosinophil

Function & Pathway5

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component (12)

Page 1 of 2

Molecular Function (3)

Biological Process (3)

Mediation Categories (3)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediation

Relations & Evidence18

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SVIL	PLK1	P53350	S	238	phosphorylation	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:23750008
SVIL	PRKDC	P78527	T	852	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
actin_regulation_adhesome	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PLK1	P53350	SVIL	O95425	Yes	Yes	No	Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:23750008 SIGNOR:23750008 PhosphoSite:23750008

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ALDH18A1 ASF1A CBX8 H2AX H3C11 H4C4 HAT1 HDAC1 SVIL	O14929 O95425 P16104 P54886 P62805 P68431 Q13547 Q9HC52 Q9Y294	1:1:1:1:3:5:1:1:1	NetworkBlastCompleat	Compleat:HC6381
ALDH18A1 CBX1 CBX3 CBX5 H1-4 H1-5 MPPED2 POGZ SVIL VGLL4	O95425 P10412 P16401 P45973 P54886 P83916 Q13185 Q14135 Q15777 Q7Z3K3	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4100
ALDH18A1 ASF1A CBX1 CBX3 CBX5 DEK H3C11 H4C4 MPHOSPH8 SSRP1 SVIL	O95425 P35659 P45973 P54886 P62805 P68431 P83916 Q08945 Q13185 Q99549 Q9Y294	1:1:1:1:1:5:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4165
ALDH18A1 CBX1 CBX3 CBX5 DEK H3C11 MPHOSPH8 SSRP1 SVIL	O95425 P35659 P45973 P54886 P68431 P83916 Q08945 Q13185 Q99549	1:1:1:1:7:1:1:1:1	NetworkBlastCompleat	Compleat:HC5659
ALDH18A1 CBX1 CBX3 CBX5 H3C11 H4C4 RACK1 SVIL TTPA	O95425 P45973 P49638 P54886 P62805 P63244 P68431 P83916 Q13185	1:1:1:1:1:1:7:1:1	NetworkBlastCompleat	Compleat:HC5482

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	3	30550287 33709510 40098346

Sequence, Structure & Domains15

Sequences

Length

2,214

Mass

247,746

Sequence

MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASESVTQRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENASECSWVASATQNVPKPPSLTVLEGDGRDSPVLHVCESKAEEEEGEGEGEEKEEDVCFTEALEQSKKTLLALEGDGLVRSPEDPSRNEDFGKPAVSTVTLEHQKELENVAQPPQAPHQPTERTGRSEMVLYIQSEPVSQDAKPTGHNREASKKRKVRTRSLSDFTGPPQLQALKYKDPASRRELELPSSKTEGPYGEISMLDTKVSVAQLRSAFLASANACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPGESRKTSERFRTQPITSAERKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Archvillin, p250, SV2; IsoId=O95425-1; Sequence=Displayed; Name=2; Synonyms=Supervillin, p205, SV1; IsoId=O95425-2; Sequence=VSP_012425, VSP_012426; Name=SV3; IsoId=O95425-3; Sequence=VSP_053768; Name=SV4; IsoId=O95425-4; Sequence=VSP_012426

Alternative Sequence

276..669; Missing (in isoform 2); 276..302; Missing (in isoform SV3); 750..781; Missing (in isoform 2 and isoform SV4)

3D Structural Models

Helix

2159..2162; 2177..2179; 2182..2188; 2193..2196; 2201..2211

Beta Strand

2169..2172; 2189..2191

3D Structure

NMR spectroscopy (2)

Domain & Motif Annotations

Compositional Bias

139..161; Basic and acidic residues; 226..239; Low complexity; 251..263; Low complexity; 280..291; Basic and acidic residues; 305..316; Basic and acidic residues; 412..426; Basic and acidic residues; 427..444; Acidic residues; 467..478; Basic and acidic residues; 561..572; Basic and acidic residues; 609..621; Basic and acidic residues; 647..656; Basic and acidic residues; 663..673; Basic and acidic residues; 791..803; Basic and acidic residues

Repeat

1441..1540; Gelsolin-like 1; 1560..1682; Gelsolin-like 2; 1752..1862; Gelsolin-like 3; 1881..1982; Gelsolin-like 4; 2015..2122; Gelsolin-like 5

Domain (CC)

As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop).

Domain (FT)

2151..2214; HP

Region

1..174; Interaction with MYLK; 36..100; Disordered; 118..334; Disordered; 346..375; Disordered; 396..447; Disordered; 460..584; Disordered; 608..687; Disordered; 781..810; Disordered; 1145..1166; Disordered; 1419..1687; Interaction with NEB

Protein Families

Villin/gelsolin family

Sequence Similarities

Belongs to the villin/gelsolin family.

Clinical Relevance6

Disease Involvement (3)

Desmin-related myopathyDisease variantMyofibrillar myopathy

Drug Targets

Literature-reported target

Antibody (4)

CAB010878 HPA020095 HPA020138 CAB080402

Interaction Protein

ENSG00000077549

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available