Protein detail
SVIL
Supervillin (Archvillin) (p205/p250)
Entry name SVIL | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Supervillin (Archvillin) (p205/p250)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Ensembl
Entrez Gene Symbol
Gene Description
Supervillin
Chromosome
10
Position
29457338-29736959
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificlungCell SpecificcDCSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificeosinophil
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SVIL | PLK1 | P53350 | S | 238 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23750008 |
| SVIL | PRKDC | P78527 | T | 852 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| actin_regulation_adhesome | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PLK1 | P53350 | SVIL | O95425 | Yes | Yes | No | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23750008SIGNOR:23750008PhosphoSite:23750008 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ALDH18A1ASF1ACBX8H2AXH3C11H4C4HAT1HDAC1SVIL | O14929O95425P16104P54886P62805P68431Q13547Q9HC52Q9Y294 | 1:1:1:1:3:5:1:1:1 | NetworkBlastCompleat | Compleat:HC6381 | ||
| ALDH18A1CBX1CBX3CBX5H1-4H1-5MPPED2POGZSVILVGLL4 | O95425P10412P16401P45973P54886P83916Q13185Q14135Q15777Q7Z3K3 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4100 | ||
| ALDH18A1ASF1ACBX1CBX3CBX5DEKH3C11H4C4MPHOSPH8SSRP1SVIL | O95425P35659P45973P54886P62805P68431P83916Q08945Q13185Q99549Q9Y294 | 1:1:1:1:1:5:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4165 | ||
| ALDH18A1CBX1CBX3CBX5DEKH3C11MPHOSPH8SSRP1SVIL | O95425P35659P45973P54886P68431P83916Q08945Q13185Q99549 | 1:1:1:1:7:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5659 | ||
| ALDH18A1CBX1CBX3CBX5H3C11H4C4RACK1SVILTTPA | O95425P45973P49638P54886P62805P63244P68431P83916Q13185 | 1:1:1:1:1:1:7:1:1 | NetworkBlastCompleat | Compleat:HC5482 |
Sequence, Structure & Domains
Sequences
Length
2,214
Mass
247,746
Sequence
MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASESVTQRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENASECSWVASATQNVPKPPSLTVLEGDGRDSPVLHVCESKAEEEEGEGEGEEKEEDVCFTEALEQSKKTLLALEGDGLVRSPEDPSRNEDFGKPAVSTVTLEHQKELENVAQPPQAPHQPTERTGRSEMVLYIQSEPVSQDAKPTGHNREASKKRKVRTRSLSDFTGPPQLQALKYKDPASRRELELPSSKTEGPYGEISMLDTKVSVAQLRSAFLASANACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPGESRKTSERFRTQPITSAERKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Archvillin, p250, SV2; IsoId=O95425-1; Sequence=Displayed; Name=2; Synonyms=Supervillin, p205, SV1; IsoId=O95425-2; Sequence=VSP_012425, VSP_012426; Name=SV3; IsoId=O95425-3; Sequence=VSP_053768; Name=SV4; IsoId=O95425-4; Sequence=VSP_012426
Alternative Sequence
276..669; Missing (in isoform 2); 276..302; Missing (in isoform SV3); 750..781; Missing (in isoform 2 and isoform SV4)
3D Structural Models
Helix
2159..2162; 2177..2179; 2182..2188; 2193..2196; 2201..2211
Beta Strand
2169..2172; 2189..2191
3D Structure
NMR spectroscopy (2)
Domain & Motif Annotations
Compositional Bias
139..161; Basic and acidic residues; 226..239; Low complexity; 251..263; Low complexity; 280..291; Basic and acidic residues; 305..316; Basic and acidic residues; 412..426; Basic and acidic residues; 427..444; Acidic residues; 467..478; Basic and acidic residues; 561..572; Basic and acidic residues; 609..621; Basic and acidic residues; 647..656; Basic and acidic residues; 663..673; Basic and acidic residues; 791..803; Basic and acidic residues
Repeat
1441..1540; Gelsolin-like 1; 1560..1682; Gelsolin-like 2; 1752..1862; Gelsolin-like 3; 1881..1982; Gelsolin-like 4; 2015..2122; Gelsolin-like 5
Domain (CC)
As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop).
Domain (FT)
2151..2214; HP
Region
1..174; Interaction with MYLK; 36..100; Disordered; 118..334; Disordered; 346..375; Disordered; 396..447; Disordered; 460..584; Disordered; 608..687; Disordered; 781..810; Disordered; 1145..1166; Disordered; 1419..1687; Interaction with NEB
Protein Families
Villin/gelsolin family
Sequence Similarities
Belongs to the villin/gelsolin family.