Protein detail

PIGN

GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (GPI-ethanolamine transferase I) (GPI-ETI) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N)

Entry name
PIGN
UniProt ID
O95427
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
15
Protein classification
Disease related genesHuman disease related genesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins
Basic Information
Protein Names
GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (GPI-ethanolamine transferase I) (GPI-ETI) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N)
Protein Class (5)
Disease related genesHuman disease related genesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
  • Predicted intracellular proteins
Transmembrane
2..24; Helical; 443..463; Helical; 483..503; Helical; 509..529; Helical; 544..564; Helical; 566..586; Helical; 592..612; Helical; 619..639; Helical; 650..670; Helical; 686..706; Helical; 724..744; Helical; 787..807; Helical; 825..845; Helical; 859..879; Helical; 895..915; Helical
Transmembrane Count
15
Ensembl
ENSG00000197563
Entrez Gene Symbol
PIGN
Gene Synonym (2)
MCD4PIG-N
Gene Description
Phosphatidylinositol glycan anchor biosynthesis class N
Chromosome
18
Position
61905255-62187118
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
PIGN fluorescence
Tissue SpecificbrainCell SpecificChoroid plexus epithelial cells
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
  • Predicted intracellular proteins
Cellular Component (4)
Molecular Function
GO:0051377 mannose-ethanolamine phosphotransferase activity
KEGG (2)
Reactome (3)
Mediation Categories
Metabolism mediation
Relations & Evidence13

Ligand-Receptor Signaling (11)

11 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PIGNTXNDC15O95427Q96J420:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry132089743
Sequence, Structure & Domains

Sequences

Length
931
Mass
105,810
Sequence
MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM

Domain & Motif Annotations

Protein Families (2)
  • PIGG/PIGN/PIGO family
  • PIGN subfamily
Sequence Similarities
Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
Clinical Relevance
Disease Involvement (2)
Disease variantEpilepsy
Related Diseases
Epilepsy
Antibody (2)
HPA039922HPA040374
Supporting Publications2
PMIDTitleRelated sentences
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available
40098346Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.No related sentences available